Interleukin-12 promotes neurite outgrowth in mouse sympathetic superior cervical ganglion neurons

Lin, H.; Hikawa, N.; Takenaka, T.; Ishikawa, Y.

Neuroscience Letters 278(3): 129-132

2000


ISSN/ISBN: 0304-3940
PMID: 10653010
DOI: 10.1016/s0304-3940(99)00913-1
Accession: 010867389

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Abstract
To determine the role of cytokines in the nervous system, we examined the effect of interleukin-12(IL-12) on the nerve regeneration of mouse superior cervical ganglion cells (SCG). IL-12 enhanced the neurite outgrowth in a concentration-dependent manner. Immunocytochemical studies demonstrated the expression of IL-12 receptors in neuronal bodies and neurites. The mRNA expression of IL-12 receptors in SCG cells was confirmed by reverse transcription-polymerase chain reaction. Our data demonstrated the presence of IL-12 receptors in sympathetic neurons and suggest that IL-12 plays an important role in neuronal regeneration.