+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Investigations into the environmental fate and effects of iopromide (ultravist), a widely used iodinated X-ray contrast medium

Investigations into the environmental fate and effects of iopromide (ultravist), a widely used iodinated X-ray contrast medium

Water Research 36(1): 266-274

lodinated X-ray contrast media are pharmaceuticals which are biologically inert and metabolically stable during their passage through the body and are excreted almost completely within a day into waste water. They are not readily biodegradable. However, in a test system simulating sewage treatment, we were able to show that the model compound iopromide (N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-methoxyacetylamino-N-methyliso-phthalamide) was amenable to primary degradation. The resulting degradation product (5-amino-N'N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-N-methyliso-phthalamide) showed a faster photolysis than the parent compound. Additionally this product was further degraded in a test system simulating surface water conditions. Short-term toxicity of the primary degradation product was low, i.e. no effects on any of various aquatic species could be found even at concentrations of 1 gl(-1). Additionally no chronic toxicity of the degradation product was observed in an early-life stage test with zebrafish at the highest tested concentration of 100mgl(-1). Based on the results from model systems a degradation pathway for iopromide is postulated. Though further work showing the transferability of the laboratory results to environmental conditions is necessary the presently available information on the environmental fate and effects of iopromide and its degradation products do not provide evidence of a risk for aquatic life caused by the introduction of this contrast medium into waste water.

(PDF emailed within 0-6 h: $19.90)

Accession: 010881050

Download citation: RISBibTeXText

PMID: 11766804

DOI: 10.1016/s0043-1354(01)00241-x

Related references

Environmental risk assessment for the widely used iodinated X-ray contrast agent iopromide (Ultravist). Ecotoxicology and Environmental Safety 42(3): 274-281, 1999

Anaerobic Transformation of the Iodinated X-ray Contrast Medium Iopromide, Its Aerobic Transformation Products, and Transfer to Further Iodinated X-ray Contrast Media. Environmental Science & Technology: -, 2018

Thyroid function in very low birthweight infants after intravenous administration of the iodinated contrast medium iopromide. Archives of Disease in Childhood. Fetal and Neonatal Edition 82(3): F215-F217, 2000

Myocardial contrast echocardiography with sonicated iopromide (Ultravist 370) before and after coronary angioplasty. Zeitschrift für Kardiologie 80(6): 367-372, 1991

Ozonation and reductive deiodination of iopromide to reduce the environmental burden of iodinated X-ray contrast media. Water Science and Technology 56(11): 159-165, 2007

Intraoperative contrast echocardiography with sonicated iopromide ultravist 370 for assessment of bypass dependent myocardial perfusion. Zeitschrift fuer Kardiologie 80(6): 373-381, 1991

Intraoperative contrast echocardiography using sonicated iopromide (Ultravist 370) for imaging the post-bypass myocardial region. Zeitschrift für Kardiologie 80(6): 373-381, 1991

The effects of low osmolality contrast medium ultravist r on osmotic diuresis. Hacettepe Medical Journal 21(2): 103-108, 1988

The Incidence, Classification, and Management of Acute Adverse Reactions to the Low-Osmolar Iodinated Contrast Media Isovue and Ultravist in Contrast-Enhanced Computed Tomography Scanning. Medicine 95(12): E3170-E3170, 2016

The effects of the iodinated X-ray contrast media iodixanol, iohexol, iopromide, and ioversol on the rat kidney epithelial cell line NRK 52-E. Renal Failure 33(4): 426-433, 2011

Renal effects of nonionic low-osmolar contrast medium iopromide. Nephrology Dialysis Transplantation 13(6): A78, June, 1998

Biodegradation of the iodinated X-ray contrast media diatrizoate and iopromide. Science of the Total Environment 225(1-2): 143-153, Jan 12, 1999

Effects of the contrast medium iopromide on renal hemodynamics and oxygen tension in the diabetic rat kidney. Advances in Experimental Medicine and Biology 530(): 653-659, 2003

Experience in using the new nonionic x-ray contrast medium Ultravist in neuroroentgenology. Zhurnal Voprosy Neirokhirurgii Imeni N. N. Burdenko: 36-37, 1993

Effects of the nonionic angiography contrast medium iopromide on contact phase activation and the coagulation system. Vasa Supplementum (32): 356-359, 1991