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Iron fortified follow on formula from 9 to 18 months improves iron status but not development or growth: a randomised trial

Iron fortified follow on formula from 9 to 18 months improves iron status but not development or growth: a randomised trial

Archives of Disease in Childhood 81(3): 247-252

Aims-Iron deficiency anaemia is associated, in observational studies, with developmental disadvantage. This study tested the hypothesis that feeding iron supplemented formula from 9 to 18 months of age would improve developmental performance. Subjects and methods-493 healthy children aged 9 months being fed pasteurised cows' milk were recruited from three UK centres. They were randomised to: cows' milk as before, formula containing 0.9 mg/litre iron, or formula containing 1.2 mg/litre iron, until 18 months of age. Bayley mental and psychomotor developmental indices were measured at 18 months, as were growth and haematological indices. Results-Children fed iron fortified formula had higher plasma ferritin concentrations, but there were no significant intergroup differences in development or growth. Conclusions-There are no developmental or growth advantages in children given iron supplemented formula, but a benefit for a minority who were anaemic, or the possibility that a benefit may emerge at a later age, cannot be excluded.

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Accession: 010885209

Download citation: RISBibTeXText

PMID: 10451399

DOI: 10.1136/adc.81.3.247

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