+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Iron intake, body iron stores and colorectal cancer risk in women: a nested case-control study

Iron intake, body iron stores and colorectal cancer risk in women: a nested case-control study

International Journal of Cancer 80(5): 693-698

Accumulated evidence suggests that increased body iron stores may increase the risk of colorectal cancer, possibly via catalyzing oxidation reactions. We examined the relationship between iron status and colorectal cancer in a case-control study nested within the New York University Women's Health Study cohort. For 105 incident cases of colorectal cancer with an average follow-up of 4.7 years and 523 individually matched controls, baseline levels of serum iron, ferritin, total iron binding capacity (TIBC) and transferrin saturation were determined as indicators of body iron stores, and total iron intake was assessed based on their diet and supplement intake. Overall, there were no associations between the risk of colorectal cancer and any of these indices except for serum ferritin, which showed a significant inverse association. When analyzed by subsite, there was an increasing trend in risk of cancer of the proximal colon with increasing total iron intake (p-value for trend = 0.04). In addition, a significantly increased risk of colorectal cancer associated with higher total iron intake (odds ratio (OR) = 2.50; 95% confidence interval (CI): 1.06-5.87) was observed among subjects with higher intake of total fat. Our results do not support a role of increased body iron stores in the development of colorectal cancer, but suggest that luminal exposure to excessive iron may possibly increase the risk in combination with a high fat diet.

(PDF emailed within 0-6 h: $19.90)

Accession: 010885229

Download citation: RISBibTeXText

PMID: 10048969

DOI: 10.1002/(sici)1097-0215(19990301)80:5<693::aid-ijc11>;2-g

Related references

Hemochromatosis gene mutations, body iron stores, dietary iron, and risk of colorectal adenoma in women. Journal of the National Cancer Institute 97(12): 917-926, 2005

A cohort study of dietary iron and heme iron intake and risk of colorectal cancer in women. British Journal of Cancer 97(1): 118-122, 2007

Iron intake and body iron stores as risk factors for Barrett's esophagus: a community-based study. American Journal of Gastroenterology 103(12): 2997-3004, 2009

Iron intake and body iron stores, anaemia and risk of hyperglycaemia among Chinese adults: the prospective Jiangsu Nutrition Study (JIN). Public Health Nutrition 13(9): 1319-1327, 2010

Body iron stores and iron restoration rate in Japanese patients with chronic hepatitis C as measured during therapeutic iron removal revealed neither increased body iron stores nor effects of C282Y and H63D mutations on iron indices. Nagoya Journal of Medical Science 64(1-2): 51-57, 2001

Both hepatic and body iron stores are increased in dysmetabolic iron overload syndrome. A case-control study. Plos One 10(6): E0128530-E0128530, 2016

Dietary iron intake, body iron stores, and the risk of type 2 diabetes: a systematic review and meta-analysis. Bmc Medicine 10: 119-119, 2013

Body iron stores, alpha-tocopherol and the risk of colorectal cancer. Anticancer Research 15(5A): 1803, 1995

Body iron stores and heme-iron intake in relation to risk of type 2 diabetes: a systematic review and meta-analysis. Plos One 7(7): E41641-E41641, 2013

Plasma ferritin and soluble transferrin receptor concentrations and body iron stores identify similar risk factors for iron deficiency but result in different estimates of the national prevalence of iron deficiency and iron-deficiency anemia among women and children in Cameroon. Journal of Nutrition 143(3): 369-377, 2013

Dietary iron intake and body iron stores are associated with risk of coronary heart disease in a meta-analysis of prospective cohort studies. Journal of Nutrition 144(3): 359-366, 2014

Serum folate, homocysteine and colorectal cancer risk in women: a nested case-control study. British Journal of Cancer 79(11-12): 1917-1922, 1999

Excess body iron and the risk of type 2 diabetes mellitus: a nested case-control in the PREDIMED (PREvention with MEDiterranean Diet) study. British Journal of Nutrition 112(11): 1896-1904, 2015

Iron stores and HFE genotypes are not related to increased risk of ischemic stroke. A prospective nested case-referent study. Cerebrovascular Diseases 24(5): 405-411, 2007

Dietary and stored iron as predictors of breast cancer risk: A nested case-control study in Shanghai. International Journal of Cancer 125(5): 1110-1117, 2009