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Iron metabolism disorders in chronic hepatitis C



Iron metabolism disorders in chronic hepatitis C



Revista Espanola de Enfermedades Digestivas 91(8): 583-589



Serum iron studies have high values in 30% of patients with virus C (HCV0 chronic hepatits even in hemochromatosis range. These indices do not represent hepatic iron storage which has a low to moderate intensity. Heterozygosity for hereditary hemochromatosis could be responsible of the iron liver storage in some patients. Nowadays the relationship between hepatic iron loading and HCV infection is unknown. It has been suggested that iron storage could allow HCV infection or, by other way. It may be caused by the infection. Iron, per se, has hepatolesive effect and acts synergistically with HCV worsening liver injury. Also, iron storage reduces the interferon response rate, and iron depletion with phlebotomies improves transaminases level. However, it is dicussed if the association: Iron removal-interferon treatment improves intereron alone treatment response. In this work all these points are reviewed.

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Accession: 010885249

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