EurekaMag.com logo
+ Site Statistics
References:
53,869,633
Abstracts:
29,686,251
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Iron metabolism in monochorionic twin pregnancies in relation to twin--twin transfusion syndrome



Iron metabolism in monochorionic twin pregnancies in relation to twin--twin transfusion syndrome



Human Reproduction 16(3): 567-573



Fetal iron metabolism was investigated in monochorionic (MC) twin pregnancies in relation to twin-twin transfusion syndrome (TTTS). Matched maternal and fetal blood samples were obtained both in utero and at birth from MC twins with TTTS (n = 23) and without TTTS (n = 18). In a second group of 30 twin pairs (15 with and 15 without TTTS), liver iron content was assessed by using archived paraffin wax-embedded blocks. Serum ferritin was determined by radioimmunoassay and values are given as gestation independent Z-scores and expressed as mean with 95% confidence intervals. Ferritin concentrations in the recipients were higher than in the donors both in utero (P < 0.01) and at birth (P < 0.01). Fetal serum ferritin in non-TTTS twins were similar to the recipient twins but higher than the donor twins (P < 0.05). A significant association was found between ferritin concentrations, the total red blood cell count and haemoglobin in the TTTS twin pairs (P < 0.01) and the non-TTTS twins as a group (P < 0.01). The total stainable liver iron was comparable between twin pairs in the TTTS and non-TTTS groups. This study fails to provide evidence of iron overload in the recipient and depletion in the donor twins and, thereby, questions the validity of the conventional theory of inter-twin transfusion as the cause of TTTS.

(PDF emailed within 0-6 h: $19.90)

Accession: 010885255

Download citation: RISBibTeXText

PMID: 11228230

DOI: 10.1093/humrep/16.3.567



Related references

Specific complications of monochorionic twin pregnancies: twin-twin transfusion syndrome and twin reversed arterial perfusion sequence. Seminars in Fetal & Neonatal Medicine 15(6): 349-356, 2011

Erythropoietin in monochorionic twin pregnancies in relation to twin--twin transfusion syndrome. Human Reproduction 16(3): 574-580, 2001

Amniotic fluid and hemodynamic model in monochorionic twin pregnancies and twin-twin transfusion syndrome. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 280(5): R1499-R1509, 2001

Nutritional supplementation in monochorionic diamniotic twin pregnancies: impact on twin-twin transfusion syndrome. American Journal of Perinatology 25(10): 667-672, 2008

Modelling the influence of amnionicity on the severity of twin-twin transfusion syndrome in monochorionic twin pregnancies. Physics in Medicine and Biology 49(6): N57-N64, 2004

Outcome of monochorionic twin pregnancies with moderate amniotic fluid discordance adjoining twin-twin transfusion syndrome. Prenatal Diagnosis 36(2): 170-176, 2016

Natural history of monochorionic diamniotic twin pregnancies with and without twin-twin transfusion syndrome. Revista Brasileira de Ginecologia E Obstetricia 31(6): 273-278, 2009

Maternal plasma and amniotic fluid cytokines in monochorionic, diamniotic twin pregnancies complicated by twin-to-twin transfusion syndrome. Fetal Diagnosis and Therapy 35(4): 280-288, 2015

Perinatal outcome in monochorionic twin pregnancies complicated by amniotic fluid discordance without severe twin-twin transfusion syndrome. Ultrasound in Obstetrics & Gynecology 27(1): 48-52, 2005

Maternal plasma and amniotic fluid angiogenic factors and their receptors in monochorionic twin pregnancies complicated by twin-to-twin transfusion syndrome. Ultrasound in Obstetrics & Gynecology 35(6): 695-701, 2010

Twin-to-twin transfusion syndrome: a case report. Antepartum prediction of underlying placental vascular pattern in monochorionic twin pregnancies may be possible. Twin Research 2(4): 286-289, 2000

Circulating angiogenic factors in monochorionic twin pregnancies complicated by twin-to-twin transfusion syndrome and selective intrauterine growth restriction. American Journal of Obstetrics and Gynecology 210(2): 141.E1-7, 2014

Haemodynamic model of twin-twin transfusion syndrome in monochorionic twin pregnancies. Placenta. -3: 195-208, Ch- Il, 1998

Assessment of cardiac function in monochorionic diamniotic twin pregnancies with twin-to-twin transfusion syndrome before and after fetoscopic laser photocoagulation using Speckle tracking. Ultraschall in der Medizin 34(2): 162-168, 2014

Influence of twin-twin transfusion syndrome on fetal cardiovascular structure and function: prospective case-control study of 136 monochorionic twin pregnancies. Heart 88(3): 271-277, 2002