+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Iron overload might increase transplant-related mortality in haematopoietic stem cell transplantation

Iron overload might increase transplant-related mortality in haematopoietic stem cell transplantation

Bone Marrow Transplantation 29(12): 987-989

Iron overload (IO) is associated with free radical generation and tissue damage. Our main objective was to ascertain if very high levels (VHL) of ferritin (>/=3000 microg/l) and transferrin saturation (TS) >/=100% during conditioning had an impact on overall survival (OS) and transplant-related mortality (TRM) after a haematopoietic stem cell transplantation (HSCT). Levels of ferritin and TS were measured at days -7 and -4, respectively, in 25 patients who underwent HSCT after CY/TBI. The group consisted of 20 men and five women with a median age of 40 years. Fifteen patients were autotransplanted and 10 allotransplanted. Nine of them had a diagnosis of AL, six of CML and 10 of lymphoma. Thirteen of them were in early and 12 in advanced status of disease. VHL of ferritin and TS >/=100% were associated with a decreased OS (P = 0.001 and P = 0.006, respectively) and an increased TRM (P = 0.003 and P = 0.004, respectively) in univariate survival analysis. Both variables remained significant at multivariate analysis for OS (P = 0.03 and 0.02, respectively) and TS was an independent factor for TRM (P = 0.01). Ferritin was very close to achieving statistical significance for TRM (P = 0.06) in multivariate analysis. In conclusion, VHL of ferritin and TS >/=100% at conditioning are associated with an increase in toxic deaths after transplant.

(PDF emailed within 0-6 h: $19.90)

Accession: 010885295

Download citation: RISBibTeXText

PMID: 12098067

DOI: 10.1038/sj.bmt.1703570

Related references

Autologous haematopoietic stem cell transplants for autoimmune disease - Feasibility and transplant-related mortality. Bone Marrow Transplantation 24(7): 729-734, Oct 1, 1999

Prognostic Impact of Post-Transplant Iron Overload After Allogeneic Stem Cell Transplantation. 2012

Toxicity of iron overload and iron overload reduction in the setting of hematopoietic stem cell transplantation for hematologic malignancies. Critical Reviews in Oncology/Hematology 113: 156-170, 2017

Tunnelled central venous catheter-related problems in the early phase of haematopoietic stem cell transplantation and effects on transplant outcome. Turkish Journal of Haematology 32(1): 51-57, 2015

Current Review of Iron Overload and Related Complications in Hematopoietic Stem Cell Transplantation. Turkish Journal of Haematology 34(1): 1-9, 2016

Allogeneic haematopoietic cell transplantation for multiple myeloma: reducing transplant-related mortality while harnessing the graft-versus-myeloma effect. European Journal of Cancer 42(11): 1601-1611, 2006

Low transplant-related mortality after second allogeneic peripheral blood stem cell transplantation with reduced-intensity conditioning in adult patients who failed a prior autologous transplant. Blood 98(11 Part 1): 420a, November 16, 2001

Danaparoid reduces transplant-related mortality in stem cell transplantation for children. Pediatric Transplantation: -, 2017

Low transplant-related mortality with allogeneic stem cell transplantation in elderly patients. Bone Marrow Transplantation 34(2): 155-159, July, 2004

Reducing transplant-related mortality after allogeneic hematopoietic stem cell transplantation. Haematologica 89(10): 1238-1247, 2004

Low transplant related mortality with allogeneic stem cell transplantation in elderly patients. Blood 102(11): 705a, November 16, 2003

Excessive T-cell depletion adversely affects transplant-related mortality following allogeneic stem cell transplantation. Blood 96(11 Part 1): 587a, November 16, 2000

Immune Reconstitution Following Allogeneic Stem Cell Transplantation The Impact of CD4+ Cell Count on Transplant Related Mortality. Blood 100(11): Abstract No 5340, November 16, 2002

Successful treatment of Epstein-Barr virus-related post-transplant lymphoproliferative disease with central nervous system involvement following allogeneic haematopoietic stem cell transplantation - a case study. Central-European Journal of Immunology 40(1): 122-125, 2015

Low transplant-related mortality from HLA-matched, T cell-depleted peripheral blood stem cell transplantation followed by donor T cell add-back for hematological malignancies. Blood 96(11 Part 1): 198a, November 16, 2000