EurekaMag.com logo
+ Site Statistics
References:
53,869,633
Abstracts:
29,686,251
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Iron status in black persons is not influenced by haptoglobin polymorphism



Iron status in black persons is not influenced by haptoglobin polymorphism



Clinical Chemistry and Laboratory Medicine 40(8): 810-813



Iron status in man is influenced by environmental and genetic factors. The molecular variation of haptoglobin is one of the genetic factors influencing iron status in Caucasians. Differences in iron metabolism between blacks and whites have been reported. We wanted to investigate the effect of haptoglobin polymorphism on iron status in blacks. We studied 300 African subjects who were apparently healthy with normal erythrocyte sedimentation rate and with no increase in dietary iron because of traditional beer consumption. We determined haptoglobin (Hp) phenotypes using starch gel electrophoresis and measured indirect iron status indices using standard methods. We compared iron status indices according to haptoglobin type. Ninety two individuals (31%) had Hp 1-1, 114 persons (38%) had Hp 2-1, 20 subjects (7%) had Hp 2-1 (Modified) and 54 individuals (18%) had Hp 2-2 type. Haptoglobin was not detectable in 19 subjects and Hp 2-1 (Johnson) was found in one subject. In both males and females, serum iron concentration, total iron binding capacity, transferrin saturation and ferritin concentration were not different with regard to Hp phenotype. These results suggest that haptoglobin phenotypic variation may not be a factor which influences iron status in black persons.

(PDF emailed within 0-6 h: $19.90)

Accession: 010885366

Download citation: RISBibTeXText

PMID: 12392310

DOI: 10.1515/CCLM.2002.140



Related references

Human iron status is genetically influenced by the haptoglobin polymorphism. Clinical Chemistry & Laboratory Medicine 37(SPEC SUPPL ): S90, June, 1999

Serum vitamin C concentration is influenced by haptoglobin polymorphism and iron status in Chinese. Clinica Chimica Acta; International Journal of Clinical Chemistry 365(1-2): 319-324, 2005

Iron nutritional status of selected elderly black persons in Washington, D.C. Journal of Nutrition for the Elderly 6(2): 3-11, 1986

Oxidative stress is genetically influenced by the haptoglobin polymorphism. Journal of the American College of Cardiology 31(2 SUPPL A): 145A-146A, 1998

Microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with iron status in persons with type 2 diabetes mellitus. American Journal of Clinical Nutrition 86(5): 1347-1353, 2007

Folacin and iron status and hematological findings in predominately black elderly persons from urban low-income households. American Journal of Clinical Nutrition 32(11): 2346-2353, 1979

Haptoglobin polymorphism and iron homeostasis. Clinical Chemistry 48(12): 2232-2235, 2002

Haptoglobin polymorphism and iron overload. Clinical Chemistry & Laboratory Medicine 39(Special Supplement): S48, 2001

Haptoglobin polymorphism and iron hemostasis. Clinical Chemistry 49(4): 708-709, 2003

Iron and infection: effects of host iron status and the iron-regulatory genes haptoglobin and NRAMPI (SLCIIAI) on host-pathogen interactions in tuberculosis and HIV. Clinical Science (London) 110(5): 503-524, 2006

Iron and infection: effects of host iron status and the iron-regulatory genes haptoglobin and NRAMP1 (SLC11A1) on host-pathogen interactions in tuberculosis and HIV. Clinical Science 110(5): 503-524, 2006

Haptoglobin polymorphism and body iron stores. Clinical Chemistry and Laboratory Medicine 40(3): 212-216, 2002

Haptoglobin polymorphism, iron metabolism and mortality in HIV infection. Aids 12(9): 1027-1032, 1998