EurekaMag.com logo
+ Site Statistics
References:
53,869,633
Abstracts:
29,686,251
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Iron status of infants fed low-iron formula: no effect of added bovine lactoferrin or nucleotides



Iron status of infants fed low-iron formula: no effect of added bovine lactoferrin or nucleotides



American Journal of Clinical Nutrition 76(4): 858-864



Background: The appropriate level of iron fortification in infant formula remains undetermined. Objectives: We compared hematologic indexes and iron-status indicators in infants who were either breast-fed or fed formula with concentrations of 2 or 4 mg Fe/L and evaluated the effects of providing part of the iron as bovine lactoferrin and of adding nucleotides. Design: Healthy term infants were exclusively breast-fed (n=16) or fed formula (n=10-12) from age 4+-2 wk to 6 mo. Anthropometric measures were taken monthly, and blood samples were taken at 1, 4, and 6 mo. Hematologic indexes; indicators of iron, zinc, and copper status; and erythrocyte fatty acids were assessed. Results: No significant differences in hematology or iron status were observed between groups at 4 and 6 mo of age. Although 34% of all infants had a hemoglobin concentration <110 g/L at 6 mo, the absence of iron deficiency or defective erythropoiesis suggests that this hemoglobin cutoff is too high for this age group. Neither the source or the concentration of iron in formula nor fortification with nucleotides had any significant effect on serum zinc or copper, and nucleotide fortification did not affect erythrocyte fatty acids. Conclusions: A concentration of 1.6 mg Fe/L formula meets the iron requirement of healthy term infants aged ltoreq6 mo, and providing more iron does not benefit iron stores. Fortification with bovine lactoferrin or nucleotides did not benefit either iron status or erythrocyte fatty acids. Additional studies are needed to establish age-appropriate cutoffs for iron deficiency and iron deficiency anemia in infancy.

(PDF emailed within 0-6 h: $19.90)

Accession: 010885377

Download citation: RISBibTeXText

PMID: 12324301

DOI: 10.1093/ajcn/76.4.858



Related references

Iron metabolism in infants: influence of bovine lactoferrin from iron-fortified formula. Nutrition 31(2): 304-309, 2015

Iron intake occult blood loss and iron status in infants 6 12 months fed formula or wcm plus iron fortified cereal. Pediatric Research 29(4 PART 2): 119A, 1991

Calcium and phosphorus supplementation of iron-fortified infant formula: no effect on iron status of healthy full-term infants. American Journal of Clinical Nutrition 65(4): 921-926, 1997

Effect of iron enrichment of prepared infant milk formula (KiNa) on the iron metabolism of young infants, as shown by oral iron loading test and total serum iron-binding capacity. Kinderarztliche Praxis 43(5): 202-210, 1975

Effect of nutrition on microbial flora in infants The role of lactoferrin, iron and nucleotides. Hanson, L A , Yolken, R H Nestle Nutrition Workshop Series; Probiotics, other nutritional factors, and intestinal microflora 189-201, 1999

Randomized double-blind controlled trial on the effects on iron status in the first year between a no added iron and standard infant formula received for three months. Acta Paediatrica 91(2): 119-124, 2002

In vivo study of the effect of lactoferrin on iron metabolism and bioavailability from different iron chemical species for formula milk fortification. Electrophoresis, 2017

Iron status of breast and formula fed infants with and without supplemental iron in 1st 12 months of life. Clinical Chemistry 24(6): 1011, 1978

Impact of whole cows milk with iron fortified cereal or formula on dietary intake and iron status of infants 6 12 months of age. Clinical Research 39(2): 646A, 1991

Iron availability from an infant formula supplemented with bovine lactoferrin. Acta Paediatrica Scandinavica 80(2): 155-158, 1991

Are extrinsic black stains of teeth iron-saturated bovine lactoferrin and a sign of iron deficient anemia or iron overload?. Medical Hypotheses 79(2): 219-221, 2012

Bioavailability of iron from infant formula supplemented with human or bovine lactoferrin. FASEB Journal 3(4): A1246, 1989

Effect of iron status on lactoferrin-iron uptake studies in Caco-2 cells. FASEB Journal 9(4): A983, 1995

Effect of supplemental lactoferrin with ferrous iron on iron status of newborn calves. Journal of dairy science 79(3): 459-464, 1996

Effect of iron solubilized by lactoferrin on iron status in adult women. Nippon Shokuhin Kagaku Kogaku Kaishi 54(10): 442-446, 2007