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Iron use for haeme synthesis is under control of the yeast frataxin homologue (Yfh1)



Iron use for haeme synthesis is under control of the yeast frataxin homologue (Yfh1)



Human Molecular Genetics 12(8): 879-889



The YFH1 gene is the yeast homologue of the human FRDA gene, which encodes the frataxin protein. Saccharomyces cerevisiae cells lacking the YFH1 gene showed very low cytochrome content. In DELTAyfh1 strains, the level of ferrochelatase (Hem15p) was very low, as a result of transcriptional repression of HEM15. However, the low amount of Hem15p was not the cause of haeme deficiency in DELTAyfh1 cells.

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Accession: 010885450

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PMID: 12668611

DOI: 10.1093/hmg/ddg096



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