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Iron, manganese, and cobalt transport by Nramp1 (Slc11a1) and Nramp2 (Slc11a2) expressed at the plasma membrane

Iron, manganese, and cobalt transport by Nramp1 (Slc11a1) and Nramp2 (Slc11a2) expressed at the plasma membrane

Blood 102(5): 1884-1892

Mutations in the Nramp1 gene (S/c11a1) cause susceptibility to infection by intracellular pathogens. The Nramp1 protein is expressed at the phagosomal membrane of macrophages and neutrophils and is a paralog of the Nramp2 (Slc11a2) iron transporter. The Nrampl transport mechanism at the phagosomal membrane has remained controversial.

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Accession: 010885476

Download citation: RISBibTeXText

PMID: 12750164

DOI: 10.1182/blood-2003-02-0425

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