+ Site Statistics
References:
52,654,530
Abstracts:
29,560,856
PMIDs:
28,072,755
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn

+ Translate
+ Recently Requested

Iron, zinc and copper levels in brain, serum and liver of neonates exposed to 2,4-dichlorophenoxyacetic acid



Iron, zinc and copper levels in brain, serum and liver of neonates exposed to 2,4-dichlorophenoxyacetic acid



Neurotoxicology & Teratology 25(5): 607-613, September-October



The effects of 2,4-dichlorophenoxyacetic acid (2,4-D, 70 or 100 mg/kg dam's body weight) on iron (Fe), zinc (Zn) and copper (Cu) in brain, liver and serum of well-nourished and undernourished pups exposed through dam's milk were determined. Undernourishment produced a high Fe decrease (serum and brain) and a delay in weight gain similar to that produced by the highest dose of 2,4-D on well-fed pups. In the latter animals, copper was found to be the most altered ion, increasing its level in serum, liver and some brain areas and decreasing in whole brain. Zinc was the most affected ion in brain areas. Well-nourished pups lactationally exposed to 70 mg 2,4-D/kg dam's body weight altered neither their metal levels nor their body weight in any of the tissues studied. Undernourished pups were more vulnerable to the 2,4-D effect than well-nourished pups. Undernourished pups exposed to a lower 2,4-D dose showed a decrease in their body, brain and liver weight similar to well-fed animals exposed to 100 mg 2,4-D/kg. A noticeable decrease in liver L-tryptophan peroxidase activity by 2,4-D was also registered. This effect was higher in undernourished and 2,4-D-exposed pups. These results suggest that brain areas have a different susceptibility to the herbicide and that undernourishment produces a higher vulnerability to the herbicide and exacerbates the 2,4-D effect.

(PDF emailed within 0-6 h: $19.90)

Accession: 010885483

Download citation: RISBibTeXText

PMID: 12972074

DOI: 10.1016/s0892-0362(03)00075-8



Related references

Zinc, copper, iron, and selenium levels in brain and liver of mice exposed to acrylonitrile. Biological Trace Element Research 130(1): 39-47, 2009

Serum copper, iron, iron-binding capacity and zinc levels in neonates. Journal of the Singapore Paediatric Society 26(1-2): 83-89, 1984

Copper, zinc, iron and manganese levels in serum, bone and liver following copper depletion. Zentralblatt für Veterinarmedizin. Reihe A 26(6): 493-496, 1979

Copper, zinc, iron and manganese levels in serum, bone and liver after copper depletion. Zentralblatt fur Veterinarmedizin Reihe A 26(6): 493-496, 1979

Iron, copper and zinc in the female system during pregnancy. II. Iron, copper and zinc levels in the blood serum, hair and saliva. Ginekologia Polska 59(9): 543-547, 1988

Effect of dietary copper iron and ascorbic acid levels on hematology blood and tissue copper iron and zinc concentrations and copper 64 and iron 59 metabolism in young pigs. Journal of Nutrition 104(5): 532-541, 1974

The prevalence of low serum zinc and copper levels and dietary habits associated with serum zinc and copper in 12- to 36-month-old children from low-income families at risk for iron deficiency. Journal of the American Dietetic Association 107(11): 1924-1929, 2007

Iron, copper and zinc levels in serum and cirrhotic liver of patients with and without hepatocellular carcinoma. Oncology 46(5): 293-296, 1989

The copper, iron and zinc levels in the blood serum of patients with chronic liver disease. Terapevticheskii Arkhiv 38(1): 50-55, 1966

Selenium, iron, copper, and zinc levels and copper-to-zinc ratios in serum of patients at different stages of viral hepatic diseases. Biological Trace Element Research 109(1): 15-24, 2006

Evaluation of serum levels of zinc, copper, iron, and zinc/copper ratio in cutaneous leishmaniasis. Iranian Journal of Arthropod-Borne Diseases 3(2): 7-11, 2009

Blood zinc, iron, and copper levels in critically ill neonates. Biological Trace Element Research 164(1): 8-11, 2016

Effects of vanadium(V) and/or chromium(III) on L-ascorbic acid and glutathione as well as iron, zinc, and copper levels in rat liver and kidney. Journal of Toxicology and Environmental Health. Part A 70(8): 696-704, 2007

Iron, copper, and zinc levels in the brain, myocardium, musculus gracilis, liver, kidney, lung, and spleen of calves and young cattle. Archiv fur experimentelle Veterinarmedizin1(2): 222-230, 1987

Zinc copper and manganese levels in the liver of the dogfish scyliorhinus canicula exposed to zinc. Bulletin of Environmental Contamination & Toxicology 31(4): 415-417, 1983