EurekaMag.com logo
+ Site Statistics
References:
53,869,633
Abstracts:
29,686,251
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Iron-sulfur clusters: Formation, perturbation, and physiological functions



Iron-sulfur clusters: Formation, perturbation, and physiological functions



Plant Physiology & Biochemistry (Paris) 37(2): 87-97



Iron-sulfur proteins occur in all life forms. Ferredoxins and Rieske proteins each contain a (2Fe-2S) cluster whereas photosystem I (PSI) contains three (4Fe-4S) clusters. Essential enzymes such as sulfite reductase, nitrite reductase, nitrogenase, glutamate synthase, aconitase, succinate dehydrogenase, ferredoxin/thioredoxin reductase, as well as many other vital proteins, each contain a (4Fe-4S) cluster. Iron-sulfur clusters are formed enzymatically from cysteinyl-sulfur and ferritin-sequestered iron. Many iron-sulfur clusters are inactivated by O2 and/or reactive oxygen species (ROS) such as O2.-. Perhaps 0.1% of the electrons passing through either the mitochondrial electron transport chain or PSI result in the formation of O2.-. Many plant stresses increase ROS formation, which subsequently may perturb iron-sulfur clusters. Plants have evolved three different superoxide dismutases (SODs) to control the internal concentrations of harmful ROS. Possible roles of functional and non-functional iron-sulfur clusters in the coordination of metabolic activities of stressed and non-stressed plants are discussed.

(PDF emailed within 0-6 h: $19.90)

Accession: 010885569

Download citation: RISBibTeXText

DOI: 10.1016/s0981-9428(99)80070-9



Related references

Characterization of iron sulfur cubane clusters by fast atom bombardment mass spectrometry the formation of ionic iron sulfur clusters through gas phase unimolecular reduction processes and their solution parallels. Journal of the American Chemical Society 114(18): 7132-7141, 1992

Characterization of the 3-iron-4-sulfur and iron-4 sulfur clusters in unbound PsaC mutants C14D and C51D: Midpoint potentials of the single 4-iron-4-sulfur clusters are identical to F-A and F-B in bound PsaC of photosystem iron. Biochemistry 32(32): 8251-8258, 1993

Low temperature magnetic circular dichroism evidence for the conversion of 4 iron sulfur clusters in a ferredoxin from clostridium pasteurianum into 3 iron sulfur clusters. Biochimica et Biophysica Acta 637(3): 423-432, 1981

Moessbauer spectroscopic evidence for the conversion of 4 iron 4 sulfur clusters in bacillus stearothermophilus ferredoxin into 3 iron 3 sulfur clusters. Febs Letters 142(1): 143-146, 1982

Conversion of 3 iron 3 sulfur into 4 iron 4 sulfur clusters in a desulfovibrio gigas ferredoxin and isotopic labeling of iron sulfur cluster subsites. Febs Letters 138(1): 55-58, 1982

Site-directed conversion of cysteine-565 to serine in PsaB of photosystem I results in the assembly of (3 iron-4-sulfur) and (4 iron-4-sulfur) clusters in F-X: A mixed-ligand (4 iron-4 sulfur) cluster is capable of electron transfer to F-A and F-B. Biochemistry 32(16): 4411-4419, 1993

Iron-sulfur stoichiometry and structure of iron-sulfur clusters in three-iron proteins: evidence for [3Fe-4S] clusters. Proceedings of the National Academy of Sciences of the United States of America 80(2): 393-396, 1983

Biological formation of iron-sulfur clusters. Journal of Inorganic Biochemistry 74(1-4): 19, April 30, 1999

Involvement of PLP in biological formation iron-sulfur clusters. Marino, G, Sannia, G, Bossa, F Advances in Life Sciences; Biochemistry of vitamin B6 and PQQ 211-215, 1994

Mechanistic and physiological implications of the interplay among iron-sulfur clusters in [FeFe]-hydrogenases. A QM/MM perspective. Journal of the American Chemical Society 133(46): 18742-9, 2012

Evidence for 2 iron 2 sulfur 3 iron x sulfur and 4 iron 4 sulfur clusters in succinate dehydrogenase. Federation Proceedings 44(3): 675, 1985

New Synthetic Routes to Iron-Sulfur Clusters: Deciphering the Repair Chemistry of [2Fe-2S] Clusters from Mononitrosyl Iron Complexes. Inorganic Chemistry 54(22): 10559-10567, 2016

Synthetic routes to iron sulfur clusters of physiological significance and related complexes of first row transition metals. Abstracts of Papers American Chemical Society 188, 1984

Structure, function, and formation of biological iron-sulfur clusters. Annual Review of Biochemistry 74: 247-281, 2005

Ground spin state variability in reduced synthetic iron sulfur clusters synthetic analogues of the reduced clusters in ferredoxins and other iron sulfur proteins cases of extreme sensitivity of electronic state and structure to extrinsic factors. Journal of the American Chemical Society 110(18): 6084-6095, 1988