EurekaMag.com logo
+ Site Statistics
References:
53,869,633
Abstracts:
29,686,251
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Iron: Metabolism and laboratory tests



Iron: Metabolism and laboratory tests



Australian Journal of Medical Science 19(4): 108-122



Iron is the most important metal in the body. During evolution oxygen and iron formed a partnership and as a result, both became essential for life. Both are capable of causing lethal tissue damage when present in excess as free radicals. To prevent tissue damage, iron became enveloped in a variety of proteins. It is the measurement of these proteins and their iron content which constitutes the most significant laboratory tests for iron and the status of iron metabolism. As each new generation of technological advances have appeared, so new tests have become available. Serum iron assays were developed in the 1920's, iron saturation in the 1940's, serum transferrin and ferritin in the 1970's and in the 1990's assays for serum erythropoietin and serum transferrin receptors have become commercially available. Iron regulatory proteins currently being characterised in cell culture research will enable us to measure iron regulation at a molecular level. This review discusses topics relevant to iron including iron chemistry, laboratory tests, iron deficiency, iron overload and a variety of current and novel therapeutic approaches to patients with disorders related to iron metabolism.

(PDF emailed within 1 workday: $29.90)

Accession: 010885576

Download citation: RISBibTeXText



Related references

Biochemical laboratory tests for the assessment of iron metabolism in the body. Wiadomosci Lekarskie 28(5): 387-392, 1975

Update information for physicians on laboratory tests: recent progress in clinical laboratory testing. Topics: II. Particulars with special emphasis on novel laboratory tests; 4. Hematological diseases, 2) Thrombosis and hemostasis laboratory tests. Nihon Naika Gakkai Zasshi. Journal of the Japanese Society of Internal Medicine 100(11): 3240-3246, 2012

Studies on iron metabolism, especially on serum iron, serum iron binding capacity and intravenous iron tolerance tests in experimental anemia. Sapporo Igaku Zasshi. Sapporo Medical Journal 19: 237-249, 1961

Diagnosis of iron deficiency: the limitations of laboratory tests in predicting response to iron treatment in 1-year-old infants. Journal of Pediatrics 99(3): 376-381, 1981

Significance of Iron(II,III) hydroxycarbonate green rust in arsenic remediation using zerovalent iron in laboratory column tests. Environmental Science and Technology 38(19): 5224-5231, 2004

Iron-replete reference intervals to increase sensitivity of hematologic and iron status laboratory tests in the elderly. Clinical Chemistry 48(9): 1586-1589, 2002

Iron deficiency in children: the relationship between pretreatment laboratory tests and subsequent hemoglobin response to iron therapy. American Journal of Clinical Nutrition 34(10): 2158-2168, 1981

Iron deficiency in women of fertile age in a Swedish community. 2. Efficiency of several laboratory tests to predict the response to iron supplementation. Acta med. scand, 185: 107-111, 1969

Diagnosis of iron deficiency in anemic 1 year old infants the limitations of laboratory tests in predicting response to iron treatment. Pediatric Research 15(4 PART 2): 586, 1981

Symptom panorama in upper secondary school students and symptoms related to iron deficiency. Screening with laboratory tests, questionnaire and interventional treatment with iron. Scandinavian Journal of Primary Health Care 23(1): 28-33, 2005

Metabolism of iron II Intravenous iron tolerance tests in Laennecs cirrhosis. 1952

Metabolism of iron. I. intravenous iron tolerance tests in normal subjects and patients with hemochromatosis. Journal of Laboratory and Clinical Medicine 39(3): 337-346, 1952

Studies on iron metabolism in infancy and childhood VIII Intravenous iron tolerance tests in experimental anemia. 1958