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Irreversible block of human heart (hH1) sodium channels by the plant alkaloid lappaconitine

Irreversible block of human heart (hH1) sodium channels by the plant alkaloid lappaconitine

Molecular Pharmacology 59(2): 183-192

The roots from Aconitum sp. plants have long been used in Chinese herbal medicine for treating pain and various heart conditions. The principal component of Aconitum remedies is usually aconitine, a site 2 neurotoxin that may induce severe neurological symptoms and cardiovascular collapse. Some Aconitum species also contain lappaconitine, the structure of which is remarkably similar to that of aconitine.

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Accession: 010885719

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PMID: 11160852

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