+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Irreversibly damaged myocardium at MR imaging with a necrotic tissue-specific contrast agent in a cat model

Irreversibly damaged myocardium at MR imaging with a necrotic tissue-specific contrast agent in a cat model

Radiology 215(3): 863-868

PURPOSE: To investigate the capability of a necrosis-avid magnetic resonance (MR) contrast agent, bis-gadolinium mesoporphyrins, for assessment of irreversibly damaged myocardium and to evaluate the time course of signal enhancement in the reperfused myocardium. MATERIALS AND METHODS: Nine cats were subjected to 90 minutes of occlusion of the left anterior descending coronary artery followed by 90 minutes of reperfusion. Contrast material-enhanced T1-weighted spin-echo images were obtained for 12 hours in five cats and 6 hours in four cats. Pathologic examinations of the resected specimens were performed with 2'3'5-triphenyl tetrazolium chloride (TTC) histochemical staining and electron microscopy. The size of enhanced area on MR images was compared with that of irreversibly damaged myocardium with TTC staining. The time course of signal enhancement was evaluated. RESULTS: The size of enhanced area on MR images was well correlated with that of irreversibly damaged myocardium with TTC staining. Maximum enhancement occurred 1-3 hours after administration of the contrast material, with mean enhancement of 171% that of normal myocardium. Electron microscopic examinations showed severe myocardial damage in the irreversibly damaged myocardium but only mild edematous changes in the reversibly damaged myocardium. CONCLUSION: MR images enhanced with bis-gadolinium mesoporphyrins provide accurate sizing of irreversibly damaged myocardium with a strong and persistent signal enhancement in the reperfused myocardium.

(PDF emailed within 0-6 h: $19.90)

Accession: 010885764

Download citation: RISBibTeXText

PMID: 10831712

DOI: 10.1148/radiology.215.3.r00jn01863

Related references

Harmonic power Doppler imaging in conjunction with contrast agent SHU 563A allows recognition of viable myocardium Experimental contrast echocardiographic studies of reperfused myocardium. Journal of the American College of Cardiology 33(2 SUPPL A): 414A, 1999

Viable myocardium can be detected by harmonic power Doppler imaging in combination with SHU 563A, a new air-filled contrast agent A contrast echocardiographic study in a canine model of acute coronary occlusion and reperfusion. European Heart Journal 20(ABSTR SUPPL ): 33, 1999

Vascular remodeling and plaque vulnerability in a rabbit model of atherosclerosis: comparison of delayed-enhancement MR imaging with an elastin-specific contrast agent and unenhanced black-blood MR imaging. Radiology 271(2): 390-399, 2014

Evaluation of the hepatocyte-specific contrast agent gadobenate dimeglumine for MR imaging of acute hepatitis in a rat model. Journal of Magnetic Resonance Imaging 7(1): 147-152, 1997

Molecular MR imaging of human thrombi in a swine model of pulmonary embolism using a fibrin-specific contrast agent. Investigative Radiology 42(8): 586-595, 2007

Clinical comparative study of tissue harmonic imaging with fundamental imaging in left-side contrast echocardiography by intravenous injection of hand-agitated perflurocarbon contrast agent. Zhongguo Chaosheng Yixue Zazhi 17(5): 346-347, 2001

Increased regional end-diastolic wall thickness early after reperfusion: a sign of irreversibly damaged myocardium. Journal of the American College of Cardiology 3(6): 1444-1453, 1984

Evaluation of bleeding sites with a tissue-specific sonographic contrast agent: preliminary experiences in an animal model. Journal of Ultrasound in Medicine 17(10): 609-16; Quiz 617-8, 1998

Magnetic resonance imaging after radiofrequency ablation in a rodent model of liver tumor: tissue characterization using a novel necrosis-avid contrast agent. European Radiology 16(5): 1031-1040, 2006

Preparation of functionalized gold nanoparticles as a targeted X-ray contrast agent for damaged bone tissue. Nanoscale 2(4): 582-586, 2010

Dynamic magnetic resonance imaging using a blood pool contrast agent to assess changes in tissue perfusion in an animal model of lower extremity ischemia. Circulation 92(8 SUPPL ): I444, 1995

Molecular magnetic resonance imaging of myocardial perfusion with EP-3600, a collagen-specific contrast agent: initial feasibility study in a swine model. Circulation 119(13): 1768-1775, 2009

Dobutamine stress echocardiography predicts reversible dysfunction and quantitates the extent of irreversibly damaged myocardium after reperfusion of anterior myocardial infarction. Journal Of The American College Of Cardiology. 24(3): 624-630, 1994

Contrast agent specific imaging modes for the ultrasonic assessment of parenchymal cerebral echo contrast enhancement. Journal of Cerebral Blood Flow and Metabolism 20(12): 1709-1716, 2000

Magnetic iron oxide for contrast enhanced mr imaging experimental investigation of an organ specific contrast agent. Acta Pharmaceutica Nordica 4(1): 64, 1992