+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Irritability following abstinence from cocaine predicts euphoric effects of cocaine administration

Irritability following abstinence from cocaine predicts euphoric effects of cocaine administration

Addictive Behaviors 28(4): 817-821, June

This study evaluated the association between negative affective symptoms during initial abstinence and euphorigenic response to experimentally administered cocaine. Cocaine-dependent individuals achieved 5 days of abstinence in a hospital setting. Forty milligrams of cocaine was given intravenously on the fifth day of abstinence, and participants were asked to rate the subjective effects produced by the drug. The associations between irritability, self-reported depression, and the subjective "high" produced by cocaine were evaluated. Increased levels of irritability and depression both correlated positively and statistically significantly with heightened response to experimentally administered cocaine as indexed by self-reported subjective "high." The positive association between irritability and subjective "high" remained after controlling for self-reported depressive symptoms. The opponent process model predicts that increased levels of negative affect should be associated with diminished euphoric response to cocaine; however, the opposite was observed. If these findings are replicated in a larger sample, then it may be necessary to reconsider the applicability of the opponent process model to cocaine addiction in humans.

(PDF emailed within 0-6 h: $19.90)

Accession: 010885842

Download citation: RISBibTeXText

PMID: 12726795

DOI: 10.1016/s0306-4603(01)00273-8

Related references

Transforming growth factor beta receptor 1 is increased following abstinence from cocaine self-administration, but not cocaine sensitization. Plos One 8(12): E83834-E83834, 2014

Abstinence from cocaine self - administration increases the percentage of accumbens neurons that encode goal - directed behaviors for cocaine. Society for Neuroscience Abstract Viewer & Itinerary Planner : Abstract No 321 7, 2003

Pharmacological evidence for an abstinence-induced switch in 5-HT1B receptor modulation of cocaine self-administration and cocaine-seeking behavior. Acs Chemical Neuroscience 5(3): 168-176, 2014

Short-term abstinence from cocaine self-administration, but not passive cocaine infusion, elevates ╬▒CaMKII autophosphorylation in the rat nucleus accumbens and medial prefrontal cortex. International Journal of Neuropsychopharmacology 17(2): 323-329, 2014

Effects of gabapentin on cocaine self-administration, cocaine-triggered relapse and cocaine-enhanced nucleus accumbens dopamine in rats. Drug and Alcohol Dependence 97(3): 207-215, 2007

Diffusion tensor imaging in cocaine dependence: regional effects of cocaine on corpus callosum and effect of cocaine administration route. Drug and Alcohol Dependence 104(3): 262-267, 2009

Acquisition of cocaine self-administration in male Sprague-Dawley rats: effects of cocaine dose but not initial locomotor response to cocaine. Psychopharmacology 219(4): 1089-1097, 2012

Cocaine dose and self-administration history, but not initial cocaine locomotor responsiveness, affects sensitization to the motivational effects of cocaine in rats. Journal of Pharmacology and Experimental Therapeutics 342(1): 214-221, 2012

Repeated administration of a mutant cocaine esterase: effects on plasma cocaine levels, cocaine-induced cardiovascular activity, and immune responses in rhesus monkeys. Journal of Pharmacology and Experimental Therapeutics 342(1): 205-213, 2012

Acute abstinence effects following smoked cocaine administration in humans. Experimental and Clinical Psychopharmacology 8(4): 472-482, 2000

Blocking cocaine's euphoric effects. Nursing Standard 1987) 9(30): 14-14, 1995

Anti-cocaine antibody and butyrylcholinesterase-derived cocaine hydrolase exert cooperative effects on cocaine pharmacokinetics and cocaine-induced locomotor activity in mice. Chemico-Biological Interactions 203(1): 212-216, 2013

Preclinical Assessment of Lisdexamfetamine as an Agonist Medication Candidate for Cocaine Addiction: Effects in Rhesus Monkeys Trained to Discriminate Cocaine or to Self-Administer Cocaine in a Cocaine Versus Food Choice Procedure. International Journal of Neuropsychopharmacology 18(8): -, 2016

Accumbal neurons that are activated during cocaine self-administration are spared from inhibitory effects of repeated cocaine self-administration. Neuropsychopharmacology 32(5): 1141-1158, 2006

Cocaine abuse versus cocaine dependence: cocaine self-administration and pharmacodynamic response in the human laboratory. Drug and Alcohol Dependence 106(1): 28-37, 2010