+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Is AIDS vaccine research at a turning point?

Is AIDS vaccine research at a turning point?

Journal of Human Virology 3(2): 83-87

Although initial anti-ENV vaccines have failed, better results may be obtained with "non-ENV" vaccines capable of inducing cell-mediated responses and perhaps mucosal reactions. A turning point in AIDS vaccine research has been reached in that there are three precise questions to answer: 1. Are the protections obtained in monkeys significant and reproducible and could they be made more frequent? 2. Can more frequent, polyepitopic, and long-lasting cell-mediated responses in human subjects be obtained? 3. Is it possible to induce significant mucosal responses? The decision as to whether phase III trials must be launched will depend on answers to these questions. It may be possible to organize international AIDS vaccine research so that these answers could be obtained in 3 to 4 years, but this would require a frank acceleration of the present endeavors.

(PDF emailed within 1 workday: $29.90)

Accession: 010885929

Download citation: RISBibTeXText

PMID: 10850894

Related references

A turning point in AIDS research The search for new frontiers. TENTH INTERNATIONAL CONFERENCE ON AIDS, INTERNATIONAL CONFERENCE ON STD Tenth International Conference on AIDS and the International Conference on STD, Vol 1; The global challenge of AIDS: Together for the future : 1) 50, 1994

AIDS: A national turning point. Report on the Third International Conference on AIDS. Midwifery 4(1): 31-36, 1988

A turning-point for AIDS?. Economist 356(8179): 77-79, 2002

Defining the objectives of the AIDS vaccine for Asia network: report of the WHO-UNAIDS/Global HIV vaccine enterprise regional consultation on expanding AIDS vaccine research and development capacity in Asia. Current Opinion in HIV and Aids 5(5): 435-452, 2011

Country ownership and the turning point for HIV/AIDS. Lancet. Global Health 1(6): E319-E320, 2015

Gloves: AIDS brought the turning point. Zahnarztliche Mitteilungen 81(15): 1466, 1468-1470, 1472, 1991

Strengthening capacity for AIDS vaccine research: analysis of the Pfizer Global Health Fellows program and the International AIDS Vaccine Initiative. Bmc Health Services Research 13(): 378-378, 2014

Enfuvirtide in the treatment of AIDS patient: the turning point. Ciencia & Saude Coletiva 15 Suppl 1: 1133-1142, 2010

AIDS vaccine research. Thumbs down on expensive, hotly debated trial of NIH AIDS vaccine. Science 321(5888): 472-472, 2008

Early treatment with zidovudine; a turning point in the campaign against AIDS?. Nederlands Tijdschrift Voor Geneeskunde 133(52): 2599-2601, 1989

Has there been a turning point in the numbers of AIDS and HIV antibody positive cases in Ireland?. Irish Journal of Medical Science 169(3): 183-186, 2001

A new turning point in glycosphingolipid research. Human Cell 18(3): 117-133, 2006

A turning point in genome research. Comptes Rendus de l'Academie des Sciences Serie III Sciences de la Vie 319(4): 247-248, 1996

A turning point for the Italian research?. Epidemiologia E Prevenzione 32(1): 3-3, 2008

Agricultural research at a turning point. Revue Nouvelle (3): 315-323, 1979