+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Is C-reactive protein a useful predictor of outcome in peritoneal dialysis patients?

Is C-reactive protein a useful predictor of outcome in peritoneal dialysis patients?

Journal of the American Society of Nephrology 12(4): 814-821

An elevated C-reactive protein (CRP) has recently been shown to be strongly predictive of mortality in hemodialysis patients. However, its predictive value in peritoneal dialysis (PD) patients has not been assessed. A cohort of 50 PD patients was followed prospectively for a 3-yr period, after initial determination of CRP. Patients with an elevated CRP (>6 mg/L; n = 29) had significantly reduced plasma prealbumin (0.36 +/- 0.02 versus 0.44 +/- 0.03 g/L; P: < 0.05), decreased total weekly creatinine clearance (C(Cr); 52.5 +/- 2.3 versus 63.1 +/- 3.2 L/1.73 m(2); P: < 0.01), and increased left ventricular thickness (1.24 +/- 0.05 versus 1.08 +/- 0.06 cm; P: < 0.05) at baseline compared with those who had a normal CRP (< or =6 mg/L; n = 21). Baseline CRP (log-transformed) correlated weakly with baseline Kt/V, C(Cr), and pre-albumin. With the use of a multivariate Cox's proportional hazards model to adjust for potential confounding factors, an elevated CRP was predictive of myocardial infarction (adjusted hazard ratio, 4.8; 95% confidence interval [CI], 1.0 to 23; P: = 0.048) and tended to be predictive of fatal myocardial infarction (adjusted hazard ratio, 6.0; 95% CI, 0.8 to 43; P: = 0.07). However, CRP was not significantly associated with all-cause mortality (adjusted hazard ratio, 2.1; 95% CI,0.8 to 5.4; P: = 0.15). In conclusion, CRP elevation occurs in a substantial proportion of PD patients and is independently predictive of future myocardial infarction. Such patients may warrant closer monitoring and attention to modifiable cardiovascular risk factors.

(PDF emailed within 1 workday: $29.90)

Accession: 010885945

Download citation: RISBibTeXText

PMID: 11274243

Related references

Peritoneal protein transport during the baseline peritoneal equilibration test is an accurate predictor of the outcome of peritoneal dialysis patients. Nephron. Clinical Practice 116(2): C104-C113, 2011

Serum C-reactive protein: a predictor of mortality in continuous ambulatory peritoneal dialysis patients. Peritoneal Dialysis International 18(4): 387-394, 1999

Is a single time point C-reactive protein predictive of outcome in peritoneal dialysis patients?. Journal of the American Society of Nephrology 14(7): 1871-1879, 2003

Serum albumin: a predictor of long-term outcome in peritoneal dialysis patients. American Journal of Kidney Diseases 23(2): 283-285, 1994

Coronary Artery Calcification Score as A Predictor of All-Cause Mortality and Cardiovascular Outcome in Peritoneal Dialysis Patients. Peritoneal Dialysis International 36(2): 163-170, 2017

Peritoneal albumin and protein losses do not predict outcome in peritoneal dialysis patients. Clinical Journal of the American Society of Nephrology 6(3): 561-566, 2011

Impact of C-reactive protein and pulse pressure evaluated at the start of peritoneal dialysis on cardiovascular events in the course of treatment with peritoneal dialysis. Peritoneal Dialysis International 30(3): 300-310, 2011

Adiponectin is related to carotid artery plaque and a predictor of cardiovascular outcome in a cohort of non-diabetic peritoneal dialysis patients. Blood Purification 26(4): 386-393, 2008

Peritoneal protein loss in patients with high peritoneal permeability: comparison between continuous ambulatory peritoneal dialysis and daytime intermittent peritoneal dialysis. Archives of Medical Research 32(3): 197-201, 2001

The relationship of prealbumin and C-reactive protein in peritoneal dialysis patients. Journal of the American Society of Nephrology 13(Program and Abstracts Issue): 203A, September, 2002

C reactive protein crp in peritoneal dialysis pd compared to hemodialysis hd patients. Journal of the American Society of Nephrology 2(3): 358, 1991

C-reactive protein and cardiovascular disease in peritoneal dialysis patients. Kidney International 62(4): 1417-1422, 2002

C-reactive protein , malnutrition and atherosclerosis in peritoneal dialysis patients. Nephrology Dialysis Transplantation 16(6): A123, June, 2001

Relevance of C-reactive protein levels in peritoneal dialysis patients. Kidney International 61(2): 615-620, 2002

CD4/CD8 T-cell ratio in peritoneal dialysis effluents predicts the outcome of peritonitis in patients undergoing continuous ambulatory peritoneal dialysis. Artificial Organs 33(12): 1091-1095, 2010