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Is C-reactive protein specific for vascular disease in women?



Is C-reactive protein specific for vascular disease in women?



Annals of Internal Medicine 136(7): 529-533



Background: C-reactive protein (CRP) predicts risk for future cardiovascular events in asymptomatic individuals. However, because CRP also predicts total mortality, its specificity for vascular disease is uncertain. Objective: To compare the predictive value of CRP for cancer and cardiovascular disease, the major determinants of mortality. Design: Prospective, nested case-control study. Setting: The Women's Health Study, an ongoing prospective cohort study involving 28 345 U.S. women 45 years of age and older who were healthy at the time of enrollment. Participants: 643 women who subsequently developed cancer or had cardiovascular events; 643 age- and smoking-matched women who remained free of either disease during 58-month follow-up. Measurements: Baseline CRP levels. Results: Little evidence showed that increasing quartiles of baseline CRP predicted incident cancer (adjusted relative risks, 1.0, 1.2, 1.1, and 1.3; P for trend >0.2). In contrast, increasing quartiles of baseline CRP were a strong marker of risk for future cardiovascular disease (adjusted relative risks, 1.0, 2.9, 3.4, and 5.6; P for trend <0.001). Conclusion: C-reactive protein appears to independently predict cardiovascular events but not cancer.

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Accession: 010885948

Download citation: RISBibTeXText

PMID: 11926788

DOI: 10.7326/0003-4819-136-7-200204020-00005



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