+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Is Campylobacter lipopolysaccharide bearing a GD3 epitope essential for the pathogenesis of Guillain-Barre syndrome?

Is Campylobacter lipopolysaccharide bearing a GD3 epitope essential for the pathogenesis of Guillain-Barre syndrome?

Acta Neurologica Scandinavica 102(2): 132-134, August

The hypothesis has been proposed that the GD3 ganglioside-like lipopolysaccharide (LPS) is essential for and functions in the development of Guillain-Barre syndrome (GBS) and Miller Fisher syndrome (MFS) subsequent to Campylobacter jejuni enteritis. Our study showed that patients with GBS or MFS who had previously suffered diarrhea had anti-GD3 antibodies less often than those who had not had diarrhea. Sera from patients who showed GBS or MFS with the serologic evidence of prior C. jejuni infection had anti-GD3 antibodies less frequently than sera from those without evidence of infection. Statistical analysis showed that anti-GD3 antibodies were less frequent in patients with GBS or MFS from whom C. jejuni had been isolated than were other anti-ganglioside antibodies, such as anti-GM1 antibodies. These results could not support the above hypothesis.

(PDF emailed within 1 workday: $29.90)

Accession: 010885960

Download citation: RISBibTeXText

PMID: 10949532

Related references

Subclass of IgG antibody to GM1 epitope-bearing lipopolysaccharide of Campylobacter jejuni in patients with Guillain-Barre syndrome. Journal of Neuroimmunology 60(1-2): 161-164, 1995

Campylobacter jejuni from patients with Guillain-Barré syndrome preferentially expresses a GD(1a)-like epitope. Infection and Immunity 70(9): 5299-5303, 2002

A case of Guillain-Barré syndrome after Campylobacter jejuni enterocolitis: anti-ganglioside antibody levels with or without Guillain-Barré syndrome. Rinsho Shinkeigaku 41(9): 625-627, 2002

Characterisation of lipopolysaccharide genes from a Guillain-Barre syndrome inducing strain of Campylobacter jejuni. IJMM International Journal of Medical Microbiology 291(Supplement 31): 126-127, September, 2001

Pathogenesis of Guillain-Barre syndrome and its relation with Campylobacter jejuni. Zhonghua Nei Ke Za Zhi 35(11): 776-778, 1996

Guillain-Barre syndrome and Campylobacter jejuni infection. A study on the etiological characteristics of Guillain-Barre syndrome in China. Chinese Medical Journal 106(11): 845-847, 1993

Experimental axonopathy induced by immunization with Campylobacter jejuni lipopolysaccharide from a patient with Guillain-Barré syndrome. Journal of Neuroimmunology 174(1-2): 12-20, 2006

Campylobacter jejuni and autoimmune-mediated neurologic diseases: pathogenesis of Guillain-Barré syndrome and Fisher's syndrome. Nihon Saikingaku Zasshi. Japanese Journal of Bacteriology 50(4): 991-1003, 1995

Role of Campylobacter jejuni infection in the pathogenesis of Guillain-Barré syndrome: an update. Biomed Research International 2013: 852195-852195, 2014

Relationship between pathogenesis of Guillain-Barre syndrome and Penner's serotypes of Campylobacter jejuni. Chinese Medical Journal 112(9): 794-796, 2001