EurekaMag.com logo
+ Site Statistics
References:
53,869,633
Abstracts:
29,686,251
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Is Crohn's disease caused by M. avium subsp. paratuberculosis?



Is Crohn's disease caused by M. avium subsp. paratuberculosis?



Proceedings of the New Zealand Society of Animal Production 62: 290-293



Speculation that M. avium subsp. paratuberculosis (MAP), the infectious agent of Johne's disease, might be involved in the aetiology of Crohn's Disease (CD) in humans was first voiced in 1913. No supportive evidence was obtained until the organism was identified in cultures from a small number of CD cases in the 1980's. Evidence accumulated over the last 15 to 20 years has left the medical community somewhat polarised about the possible role of MAP in Crohn's disease. Technological advances enabling more sensitive detection of bacteria or their components (e.g. PCR, immunohistochemistry), or immunological responses to them, have not clarified the fundamental question of whether an apparent association between the presence of MAP and CD lesions may have any causal significance. The basis for concluding that MAP has a causal role in the aetiology of CD is unconvincing.

(PDF emailed within 1 workday: $29.90)

Accession: 010885970

Download citation: RISBibTeXText



Related references

Disparate host immunity to Mycobacterium avium subsp. paratuberculosis antigens in calves inoculated with M. avium subsp. paratuberculosis, M. avium subsp. avium, M. kansasii, and M. bovis. Clinical and Vaccine Immunology 20(6): 848-857, 2013

"In vitro" activities of antimycobacterial agents against Mycobacterium avium subsp. paratuberculosis linked to Crohn's disease and paratuberculosis. Annals of Clinical Microbiology and Antimicrobials 5: 27-27, 2006

Possible association between Mycobacterium avium subsp paratuberculosis infection and Crohn's disease. Revista Medica de Chile 139(6): 794-801, 2012

Mycobacterium avium subsp. paratuberculosis in Crohn's disease is serologically positive. Clinical and Diagnostic Laboratory Immunology 6(2): 282-282, 1999

Crohn's disease and Mycobacterium avium subsp. paratuberculosis: current issues. Journal of Food Protection 64(12): 2103-2110, 2002

Mycobacterium avium subsp. paratuberculosis in food and its relationship with Crohn's disease. Revista Argentina de Microbiologia 39(1): 57-68, 2007

Crohn's disease and Mycobacterium avium subsp. paratuberculosis: current issues. Journal of Food Protection 64(12): 2103-2110, 2001

Mycobacterium avium subsp. Paratuberculosis (MAP) as a modifying factor in Crohn's disease. Inflammatory Bowel Diseases 16(2): 296-304, 2010

What Role Does Mycobacterium avium subsp. paratuberculosis Play in Crohn's Disease?. Current Infectious Disease Reports 17(2): 463-463, 2015

Review article: Mycobacterium avium subsp. paratuberculosis as one cause of Crohn's disease. Alimentary Pharmacology & Therapeutics 15(3): 337-346, 2001

Is Mycobacterium avium subsp. paratuberculosis an etiological factor in Crohn's disease?. Israel Journal of Veterinary Medicine 59(4): 60-67, He66-69, 2004

Immunogenicity of Mycobacterium avium subsp. paratuberculosis proteins in Crohn's disease patients. Scandinavian Journal of Gastroenterology 46(1): 30-39, 2011

Debate on the lack of evidence of Mycobacterium avium subsp. paratuberculosis in Crohn's disease. Inflammatory Bowel Diseases 11(12): 1123-1123, 2005

Crohn's disease and Mycobacterium avium subsp. paratuberculosis: the need for a study is long overdue. Veterinary Immunology and Immunopathology 145(1-2): 1-6, 2012

Specific seroreactivity of Crohn's disease patients against p35 and p36 antigens of M. avium subsp. paratuberculosis. Veterinary Microbiology 77(3/4): 497-504, 2000