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Knowledge-based system for method development of chiral separations with capillary electrophoresis using highly-sulphated cyclodextrins

Knowledge-based system for method development of chiral separations with capillary electrophoresis using highly-sulphated cyclodextrins

Journal of Pharmaceutical & Biomedical Analysis 27(3-4): 515-529, 15 January

Method development for chiral separations is not easy because it requires experience and many experimental possibilities can be chosen. In order to help the analyst, a knowledge-based system (KBS) for the rapid determination of experimental parameters, which allow a baseline separation of enantiomers, has been developed. On the basis of own laboratory knowledge, completed with literature data, rules were defined and a KBS was built. Five different techniques are considered in this KBS. This paper describes the capillary electrophoresis (CE) section, in which a strategy has been defined based on the use of highly-sulfated cyclodextrins as chiral selectors. A structured representation of the knowledge and its implementation in Toolbook software is presented.

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Accession: 010902088

Download citation: RISBibTeXText

PMID: 11755753

DOI: 10.1016/s0731-7085(01)00574-x

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