+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Left atrial systolic function is depressed in idiopathic and preserved in ischemic dilated cardiomyopathy



Left atrial systolic function is depressed in idiopathic and preserved in ischemic dilated cardiomyopathy



European Journal of Clinical Investigation 29(11): 905-912



Background: Left atrial systolic dysfunction, unexplained by altered loading conditions, has been reported in idiopathic dilated cardiomyopathy suggesting left atrial involvement in the myopathic process. Materials and methods: Seventeen patients with idiopathic dilated cardiomyopathy, 16 with ischemic dilated cardiomyopathy and 18 normal controls were studied with transthoracic echocardiography and cardiac catheterization. Transmitral diastolic flow was evaluated with pulsed Doppler. Left atrial volume (cm3/m2) at mitral valve opening (maximal, Vmax.), onset of atrial systole (P wave of the electrocardiogram, Vp), and mitral valve closure (minimal, Vmin.) was determined with two-dimensional echocardiography using the biplane area-length method. The left atrial active emptying fraction (ACTEF = (Vp-Vmin.) X 100/ Vp) served as an index of systolic function. Results: The peak early diastolic transmitral flow velocity (cm/sec) was similar in the three groups (idiopathic:60 +- 16, ischemic: 58 +- 20, control: 56 +- 22; P = NS), whereas the late diastolic transmitral flow velocity was lower but not significantly different in idiopathic compared to ischemic cardiomyopathy, and in both was lower than control (26 +- 12 vs. 34 +- 13 vs. 44 +- 14, respectively; P < 0.05). Vmax. and Vp were similar in idiopathic and ischemic cardiomyopathy and greater than control (44.6 +- 13.6 vs. 48.2 +- 18.3 vs. 26.9 +- 6.2; P < 0.05, and 34.6 +- 13.4 vs. 30.8 +- 10.9 vs. 16.7 +- 3.7, respectively; P < 0.05). ACTEF was lower in idiopathic than in ischemic cardiomyopathy and in the latter it was similar to control (18 +- 10% vs. 32 +- 10% vs. 36 +- 10%, respectively; P < 0.05). Moreover, ACTEF was inversely related to left atrial tension at end-of atrial systole both in idiopathic and in ischemic cardiomyopathy (r2 = 0.52, P = 0.001 and r2 = 0.57, P = 0.0007, respectively). However, at any given level of left atrial tension at end of atrial systole, ACTEF was lower in idiopathic than ischemic cardiomyopathy. Conclusion: Left atrial systolic function is depressed in idiopathic and preserved in ischemic dilated cardiomyopathy despite similar left atrial loading conditions. This finding suggests left atrial myopathy in the former, and may be related to the differences in the response to medical treatment and clinical outcome observed between the two conditions.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 010915688

Download citation: RISBibTeXText

PMID: 10583434

DOI: 10.1046/j.1365-2362.1999.00563.x


Related references

Left atrial systolic function is depressed in idiopathic and preserved in ischemic dilated cardiomyopathy. Journal of the American College of Cardiology 31(2 SUPPL A): 149A, 1998

Usefulness of isovolumic and systolic ejection signals by tissue Doppler for the assessment of left ventricular systolic function in ischemic or idiopathic dilated cardiomyopathy. American Journal of Cardiology 97(6): 872-875, 2006

Left atrial booster pump function in patients with ischemic cardiomyopathy and idiopathic dilated cardiomyopathy. Journal of the American College of Cardiology 0(SPEC ISSUE): 165A, 1995

Relation of left atrial volume and systolic function to the hormonal response in idiopathic dilated cardiomyopathy. International Journal of Cardiology 47(2): 139-143, 1994

Relation of exercise capacity to left ventricular systolic function and diastolic filling in idiopathic or ischemic dilated cardiomyopathy. American Journal of Cardiology 83(5): 728-734, March 1, 1999

Effects of carvedilol on systolic and diastolic left ventricular performance in idiopathic dilated cardiomyopathy or ischemic cardiomyopathy. American Journal of Cardiology 78(7): 779-784, 1996

The differences in left atrial function between ischemic and idiopathic dilated cardiomyopathy patients: A two-dimensional speckle tracking imaging study. Journal of Clinical Ultrasound 44(7): 437-445, 2016

Effects of darbepoetin alpha on right and left ventricular systolic and diastolic function in anemic patients with chronic heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. American Heart Journal 155(4): 751.E1-7, 2008

Left atrial systolic reserve in idiopathic vs. ischaemic-dilated cardiomyopathy. European Journal of Clinical Investigation 35(6): 355-361, 2005

Prognostic value of left atrial enlargement in patients with idiopathic dilated cardiomyopathy and ischemic cardiomyopathy. American Journal of Cardiology 89(5): 518-523, March 1, 2002

Association between left atrial myocardial function and exercise capacity in patients with either idiopathic or ischemic dilated cardiomyopathy: a two-dimensional speckle strain study. International Journal of Cardiology 132(3): 354-363, 2008

Preserved coronary endothelial vasomotor function in idiopathic dilated cardiomyopathy A predictor for recovery of systolic performance. European Heart Journal 22(Abstract Supplement): 260, September, 2001

Effects of darbepoetin alpha on right and left ventricular systolic secondary to ischemic or idiopathic dilated cardiomyopathy. American Heart Journal 155(4): Article No.: e7, 2008

Frequency of left atrial thrombi by transesophageal echocardiography in idiopathic and in ischemic dilated cardiomyopathy. American Journal of Cardiology 70(18): 1500-1501, 1992

Relation of exercise capacity in dilated cardiomyopathy to left atrial size and systolic function. American Journal of Cardiology 70(7): 825-827, 1992