+ Site Statistics
References:
52,654,530
Abstracts:
29,560,856
PMIDs:
28,072,755
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn

+ Translate
+ Recently Requested

Lung cancer screening in cigarette smokers in the province of Varese, Italy



Lung cancer screening in cigarette smokers in the province of Varese, Italy



Cancer 89(11): 2345-2348, December 1



BACKGROUND. For heavy cigarette smokers and recent former smokers who have accumulated a high risk of lung carcinoma, a primary objective is the early detection of that disease; this goal can be achieved by annual screening with one of the radiologic imaging methods available. While awaiting for the implementation of computed tomography or of other, more sensitive methods, it is quite reasonable to screen those who are at risk with annual chest X-ray (CXR), an examination that is readily available at low cost. Indeed, with the annual CXR screening of heavy smokers, it is possible to detect about 50% of lung carcinomas in TNM Stage I. The 5-year survival rate of patients with asymptomatic, screen-detected Stage I disease after radical surgery is significantly greater than the survival rate of patients with symptomatic disease. METHODS. At the Center for Thoracic Surgery of the University of Insubria Medical School in Varese we developed a project, called "PRE.DI.CA" (an acronym for "early diagnosis of cancer"), of annual CXR screening for the early diagnosis of asymptomatic lung carcinoma in the high risk population of heavy cigarette smokers and recent former smokers in the province of Varese, Italy. From June 1997 to August 1999, 2444 heavy smokers were enrolled in the PRE.DI.CA project. RESULTS. About 75% of participants complied with the annual screening protocol. Overall, 23 patients (all males) with asymptomatic lung carcinoma were detected by CXR screening; moreover, 1 patient developed symptoms of lung carcinoma 6 months after his initially negative CXR and was diagnosed with interval carcinoma (Stage IIIA). In the initial (prevalence) screening, the authors detected 16 patients with lung carcinoma in 2444 screened participants (0.65%). In the subsequent incidence screening, the authors detected 7 patients with lung carcinoma in 1361 screened participants (0.51%); it is noteworthy that 5 of 7 patients (71%) with lung carcinoma that was detected by incidence CXR screening had Stage I disease. CONCLUSIONS. In the province of Varese, Italy, it is possible to make an early diagnosis of lung carcinoma with CXR annual screening in asymptomatic, high risk smokers. Incidence screening in 1361 participants detected 7 patients with asymptomatic lung carcinoma; 5 of 7 patients (71%) with such screen-detected lung carcinoma had Stage I disease.

(PDF emailed within 0-6 h: $19.90)

Accession: 010943305

Download citation: RISBibTeXText

DOI: 10.1002/1097-0142(20001201)89:11+<2345::aid-cncr5>3.0.co;2-b



Related references

Lung cancer screening in cigarette smokers in the province of Varese, Italy. Cancer 89(11 Suppl): 2345-2348, 2001

Assessment of lung cancer mortality reduction after chest X-ray screening in smokers: a population-based cohort study in Varese, Italy. Lung Cancer 80(1): 50-54, 2013

Self-selection effects in smokers attending lung cancer screening: a 9.5-year population-based cohort study in Varese, Italy. Journal of Thoracic Oncology 5(4): 428-435, 2010

Prevalence of heavy smokers in the year 2000 in the province of Varese, Italy. Monaldi Archives for Chest Disease 73(4): 152-154, 2011

Western Australian cigarette smokers have fewer small lung nodules than North Americans on CT screening for lung cancer. Journal of Medical Imaging and Radiation Oncology 53(4): 339-344, 2009

The PRE.DI.CA. project for radiographic lung cancer screening in cigarette smokers. Rays 29(4): 383-385, 2005

Is chest X-ray screening for lung cancer in smokers cost-effective? Evidence from a population-based study in Italy. Cost Effectiveness and Resource Allocation 13(): 15-15, 2015

Lung cancer death rates among non-smokers and pipe and cigarette smokers. Brit Med Jour (4945): 923-929, 1955

Differences in epidemiology, histology, and survival between cigarette smokers and never-smokers who develop non-small cell lung cancer. Chest 132(1): 185-192, 2007

Lung cancer death rates among non-smokers and pipe and cigarette smokers; an evaluation in relation to air pollution by benzpyrene and other substances. British Medical Journal 2(4945): 923-929, 1955

Changes in lung cancer histological types in Varese Cancer Registry, Italy 1976-1992. European Journal Of Cancer. 33(10): 1643-1647, 1997

Resection rate of lung cancer in Teesside (UK) and Varese (Italy): a comparison after implementation of the National Cancer Plan. Thorax 71(3): 230-237, 2016

Lung cancer in Teesside (UK) and Varese (Italy): a comparison of management and survival. Thorax 61(3): 232-239, 2005