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Male partner screening before in vitro fertilization: Preselecting patients who require intracytoplasmic sperm injection with the sperm penetration assay



Male partner screening before in vitro fertilization: Preselecting patients who require intracytoplasmic sperm injection with the sperm penetration assay



Fertility & Sterility 76(6): 1113-1118



Objectives: To determine the diagnostic accuracy of the sperm penetration assay (SPA) and standard semen parameters for subsequent fertilization in in vitro fertilization-embryo transfer (IVF-ET). Design: Prospective study. Setting: Andrology Laboratory, and university research laboratory. Patients: Two hundred sixteen couples undergoing male-partner screening before IVF-ET (265 cycles). Intervention(s): Male-partner screening (semen analyses (SA) and SPA), standard IVF-ET procedures, follow-up of fertilization in IVF-ET. Main Outcome Measure(s): Diagnostic accuracy of SA and SPA for prediction of fertilization in IVF-ET. Result(s): The SPA predicted IVF fertilization with high negative (84%) and positive (98%) predictive rates, and correct prediction in 88% of cycles. In contrast, sperm concentration, motility, morphology, and complete SA showed poor diagnostic accuracy, with correct prediction of IVF fertilization in 64%, 65%, 45%, and 68% of cycles, respectively. Conclusion(s): Very low sperm concentration and/or motility were good predictors of poor IVF fertilization, however, low to normal semen parameters were not predictive of successful IVF fertilization. The SPA is a useful screening tool that predicts IVF fertilization with high diagnostic accuracy. The SPA may be useful to discriminate between those couples with a high probability of normal fertilization in IVF and those with a low probability of normal fertilization that may benefit from assisted fertilization by intracytoplasmic sperm injection (ICSI).

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Accession: 010951452

Download citation: RISBibTeXText

PMID: 11730736

DOI: 10.1016/s0015-0282(01)02890-4


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