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Manganese stimulation and stereospecificity of the Dopa (3,4-dihydroxyphenylalanine) /tyrosine-sulfating activity of human monoamine-form phenol sulfotransferase. Kinetic studies of the mechanism using wild-type and mutant enzymes

Pai, T.Govind.; Ohkimoto, K.; Sakakibara, Y.; Suiko, M.; Sugahara, T.; Liu, M-Cheh.

Journal of Biological Chemistry 277(46): 43813-43820

2002


ISSN/ISBN: 0021-9258
PMID: 12228221
DOI: 10.1074/jbc.m200785200
Accession: 010954992

Kinetic studies were performed to dissect the mechanism underlying the remarkable Mn2+ stimulation of the Dopa/tyrosine-sulfating activity of the human monoamine (M)-form phenol sulfotransferase (PST). The activities and the stimulation by Mn2+ are highly stereospecific for the D-form enantiomers of tyrosine and Dopa.

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