+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Melatonin and retinyl acetate as chemopreventives in DMBA-induced mammary carcinogenesis in female Sprague-Dawley rats



Melatonin and retinyl acetate as chemopreventives in DMBA-induced mammary carcinogenesis in female Sprague-Dawley rats



Folia Biologica 46(2): 69-72



One goal of experimental oncology is to find and test effective chemopreventive substances which can suppress malignant transformation of the cells, their accumulation and invasion. Mammary gland tumours were induced by DMBA applied intragastrically (10 mg/rat, three times) every three days between postnatal days 50 and 60 in female Sprague-Dawley rats. One day after the last dose we started chemoprevention with Mel, RA and combination of both drugs, which lasted 25 weeks. Mel was drunk continuously as a solution in tap water (100 micrograms/ml). RA was applied daily in the dose of 8.2 mg/rat at the base of the tongue. There were four experimental groups: 1. control--no chemoprevention, 2. Mel treatment, 3. RA treatment, 4. application RA + Mel. At the end of the experiment the incidence, frequency, latency and average volume of tumours were evaluated. In the group treated with Mel tumour incidence, latency and volume did not differ from controls; the frequency of tumours was decreased. Treatment with RA and with combination RA + Mel decreased mammary tumour incidence to 38% (RA) and 48% (RA + Mel); it also decreased frequency and prolonged latency. Thus chemoprotective effects of RA and combination of RA with Mel were proved in mammary carcinogenesis induced by DMBA. The oncostatic effect of Mel alone was not confirmed. In our recent paper (Bojková et al., 2000) drinking of lower doses of Mel during the late afternoon and night prolonged the latency period and in combination with RA showed an oncostatic effect on mammary carcinogenesis induced by NMU. Further studies are needed to elucidate the conditions of successful chemoprevention with Mel.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 010971680

Download citation: RISBibTeXText

PMID: 10813093


Related references

Growth arrest induced by wild-type p53 protein blocks cells prior to or near the restriction point in late G1 phase. Proceedings of the National Academy of Sciences of the United States of America 89(19): 9210-9214, 1992

Effects of a locus affecting floral pigmentation in Ipomoea purpurea on female fitness components. Genetics 134(4): 1237-1247, 1993

Phenoxodiol, a novel approach for the treatment of ovarian cancer. Current Opinion in Investigational Drugs 7(6): 542-548, 2006

Synergistic effect of IL-4 and TNF-alpha in the induction of monocytic differentiation of a mouse myeloid leukaemic cell line (WEHI-3B JCS). Immunology 81(1): 65-72, 1994

Synergistic effect of KRN7000 with interleukin-15, -7, and -2 on the expansion of human V alpha 24+V beta 11+ T cells in vitro. Human Immunology 61(4): 357-365, 2000

Lack of chart reminder effectiveness on family medicine resident JNC-VI and NCEP III guideline knowledge and attitudes. Bmc Family Practice 5: 14, 2004

Preventive effect of hyaluronic acid on the suppression of attachment and migration abilities of bovine chondrocytes by IL-1alpha in vitro. Journal of Veterinary Medical Science 65(3): 427-430, 2003

Synergistic effect of stromelysin-1 promoter 5a/6a polymorphism with smoking on the onset of young acute myocardial infarction. European Heart Journal 24(Abstract Supplement): 449, August-September, 2003

Positive temperature coefficients in pure quadrupole resonance. Journal of Molecular Structure 58: 121-141, 1980

Nimesulide and diclofenac inhibit lipopolysaccharide-induced hypothermia and tumour necrosis factor-alpha elevation in rats. Fundamental and Clinical Pharmacology 16(4): 303-309, 2002

Growth arrest of 8 colon carcinoma cell lines by combined treatment with differentiation and cytotoxic agents. Anticancer Research 17(5C): 3967-3968, 1997

Retinoylation of proteins in rat hepatocytes following uptake of chylomicron remnant retinyl ester. Scandinavian Journal of Clinical and Laboratory Investigation 59(5): 315-324, 1999

Charles Remington's contributions to the species concept. Journal of the Lepidopterists' Society. 11 October; 503: 268-270, 1996

Positive tumor scintigraphy with 99mTc pertechnetate and 99mTc pyrophosphate in children. Radiologia Diagnostica 24(1): 59-66, 1983

Chemopreventive potential of ferulic acid in 7,12-dimethylbenz[a]anthracene-induced mammary carcinogenesis in Sprague-Dawley rats. European Journal of Pharmacology 637(1-3): 22-29, 2010