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Neo-adjuvant chemo-(immuno)-therapy of advanced squamous-cell head and neck carcinoma: A multicenter, phase III, randomized study comparing cisplatin plus 5-fluorouracil (5-FU) with cisplatin plus 5-FU plus recombinant interleukin 2



Neo-adjuvant chemo-(immuno)-therapy of advanced squamous-cell head and neck carcinoma: A multicenter, phase III, randomized study comparing cisplatin plus 5-fluorouracil (5-FU) with cisplatin plus 5-FU plus recombinant interleukin 2



Cancer Immunology Immunotherapy 47(3): 149-156



We carried out an open, randomized, phase III, multicenter clinical trial to compare, in neo-adjuvant setting, the clinical response and toxicity of the combination chemotherapy cisplatin + 5-FU with the same combination plus s.c. recombinant interleukin-2 (rIL-2) in patients with advanced (stage III-IV) head and neck squamous-cell carcinoma (HNSCC).

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Neo-adjuvant chemo-(immuno-)therapy of advanced squamous-cell head and neck carcinoma: a multicenter, phase III, randomized study comparing cisplatin + 5-fluorouracil (5-FU) with cisplatin + 5-FU + recombinant interleukin 2. Cancer Immunology, ImmunoTherapy 47(3): 149-156, 1998

Neo-adjuvant chemo- -therapy of advanced squamous-cell head and neck carcinoma A multicenter, phase III, randomized study comparing cisplatin plus 5-fluorouracil with cisplatin plus 5-FU plus recombinant interleukin 2. Cancer Immunology Immunotherapy 47(3): 149-156, 1998

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