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Nicotine-induced locomotor activity is increased by preexposure of rats to prenatal stress



Nicotine-induced locomotor activity is increased by preexposure of rats to prenatal stress



Brain Research 882(1-2): 196-200, 3 November



Genetics factors are believed to play a predominant role in the individual differences observed in behavioral and pharmacological responses to drugs of abuse. An increasing literature indicates, however, that epigenetic factors can be involved as well. In this report we examined whether developmental changes induced by prenatal stress could alter the way animals respond to the psychostimulant effect of nicotine when adults. The results show that nicotine induces a dose-dependent increase of locomotor activity in both groups, and that prenatally-stressed animals exhibit a higher behavioral response at all doses. This study emphasizes the importance of early environment in the later development of drug-related behavior.

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Accession: 011058659

Download citation: RISBibTeXText

PMID: 11056199

DOI: 10.1016/s0006-8993(00)02803-1


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