EurekaMag
+ Most Popular
Cunninghamia lanceolata plantations in China
Mammalian lairs in paleo ecological studies and palynology
Studies on technological possibilities in utilization of anhydrous milk fat for production of recombined butter-like products
Should right-sided fibroelastomas be operated upon?
Large esophageal lipoma
Apoptosis in the mammalian thymus during normal histogenesis and under various in vitro and in vivo experimental conditions
Poissons characoides nouveaux ou non signales de l'Ilha do Bananal, Bresil
Desensitizing efficacy of Colgate Sensitive Maximum Strength and Fresh Mint Sensodyne dentifrices
Administration of fluid by subcutaneous infusion: revival of a forgotten method
Tundra mosquito control - an impossible dream?
Schizophrenia for primary care providers: how to contribute to the care of a vulnerable patient population
Geochemical pattern analysis; method of describing the Southeastern limestone regional aquifer system
Incidence of low birth weights in a hospital of Mexico City
Tabanidae
Graded management intensity of grassland systems for enhancing floristic diversity
Microbiology and biochemistry of cheese and fermented milk
The ember tetra: a new pygmy characid tetra from the Rio das Mortes, Brazil, Hyphessobrycon amandae sp. n. (Pisces, Characoidei)
Risk factors of contrast-induced nephropathy in patients after coronary artery intervention
Renovation of onsite domestic wastewater in a poorly drained soil
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Systolic blood pressure in a population of infants in the first year of life: the Brompton study
Haematological studies in rats fed with metanil yellow
Studies on pasteurellosis. I. A new species of Pasteurella encountered in chronic fowl cholera
Dormancy breaking and germination of Acacia salicina Lindl. seeds
therapy of lupus nephritis. a two-year prospective study

Opioid peptide pharmacology and immunocytochemistry in an animal model of self-sustaining status epilepticus


Opioid peptide pharmacology and immunocytochemistry in an animal model of self-sustaining status epilepticus



Neuroscience 89(1): 167-173



ISSN/ISBN: 0306-4522

PMID: 10051226

DOI: 10.1016/s0306-4522(98)00320-0

In a model of self-sustaining status epilepticus induced in rats by 30 min intermittent stimulation of the perforant path through chronically implanted electrodes, a decrease in dynorphin-like immunoreactivity in the dentate gyrus and CA3 was observed 3 h and 24 h after the induction of status epilepticus. Enkephalin-like immunoreactivity decreased 3 h but not 24 h after perforant path stimulation. Injection into the hilus of the dentate gyrus 10 min prior to stimulation of the kappa-receptor agonist dynorphin-A(1-13), the delta-receptor antagonists ICI-174864 and naltrindole, as well as i.p. injection of naloxone prevented the development of status epilepticus. Perihilar administration of the delta-agonist (D-Ser2)Leu-enkephalin-Thr6 or the kappa- antagonist nor-Binaltorphimine, but not of the mu-agonist (D-Ala2,N-Me-Phe4,Gly-ol5)-Enkephalin, facilitated the establishment of self-sustaining status epilepticus. Injection into the hilus of dynorphin-A(1-13) after the end of perforant path stimulation, stopped established status epilepticus, while administration of naloxone, naltrindole and ICI-174864 were ineffective. We conclude that kappa-opioids in the hippocampus counteract initiation and maintenance of status epilepticus, while delta-opioids promote initiation, but not maintenance of seizure activity. These data are important for the understanding the mechanisms which underlie initiation and maintenance of status epilepticus and for the development of new approaches for its effective management.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 011092253

Download citation: RISBibTeXText

Related references

Opioid-mediated modulation of self-sustaining status epilepticus. Epilepsia 38(Suppl. 8): 19, 1997

A rodent model of focally evoked self-sustaining status epilepticus. European Journal of Pharmacology 221(1): 151-155, 1992

Self-sustaining status epilepticus: A condition maintained by potentiation of glutamate receptors and by plastic changes in substance P and other peptide neuromodulators. Epilepsia 41 Suppl. 6: S134-S143, 2000

Anticonvulsant effect of dexmedetomidine in a rat model of self-sustaining status epilepticus with prolonged amygdala stimulation. Neuroscience Letters 543: 17-21, 2013

Opioid peptide release in the rat hippocampus after kainic acid-induced status epilepticus. Hippocampus 13(4): 472-480, 2003

An animal model of absence status epilepticus. Epilepsia 42(Suppl. 7): 132, 2001

Intravenous felbamate in an animal model of status epilepticus. Epilepsia 39(Suppl. 6): 42-43, 1998

Late treatment in an animal model of status epilepticus. Epilepsia 37(Suppl. 5): 70, 1996

Epileptogenesis after self-sustaining status epilepticus. Epilepsia 43 Suppl. 5: 74-80, 2002

Ontogeny of self-sustaining status epilepticus. Developmental Neuroscience 21(3-5): 345-351, 1999

Ontogeny of Self-Sustaining Status epilepticus. Developmental Neuroscience 21(3-5): 345-351, 1999

Loss of phase synchrony in an animal model of partial status epilepticus. Neuroscience 148(1): 304-313, 2007

An animal model of nonconvulsive status epilepticus: A contribution to clinical controversies. Epilepsia 42(2): 171-180, 2001

Comparison of anticonvulsant effects of neuropeptides in animal model of status epilepticus. Epilepsia 42(Suppl. 7): 131, 2001

Hyponatremia augments kainic-acid induced status epilepticus in the mouse: a model for dysmetabolic status epilepticus. Epilepsy Research 106(1-2): 29-34, 2013