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PTEN controls immunoreceptor (immunoreceptor tyrosine-based activation motif) signaling and the activation of Rac



PTEN controls immunoreceptor (immunoreceptor tyrosine-based activation motif) signaling and the activation of Rac



Blood 99(2): 694-697



Fcgamma receptor-mediated phagocytosis is a model for the study of immunoreceptor (immunoreceptor tyrosine-based activation motif (ITAM)) signaling and involves the activation of protein tyrosine kinases, protein tyrosine phosphatases, and downstream effectors including phosphatidylinositol-3 (PI-3) kinase. Relatively little is known of the role of lipid phosphatases in the control of ITAM signaling and inflammation.

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Accession: 011112128

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PMID: 11781256


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