+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Peculiarities of blood platelets serotonin system in patients with different clinical manifestations of schizoaffective psychosis



Peculiarities of blood platelets serotonin system in patients with different clinical manifestations of schizoaffective psychosis



Zhurnal Nevrologii i Psikhiatrii Imeni S S Korsakova 100(5): 50-54



45 women with different manifestations of schizoaffective psychosis (SAP) were examined. The diagnosis corresponded to ICD-10 (F25). According to the classification elaborated in Mental Health Research Centre of Russian Academy of Medical Sciences, groups of patients were identified with different variants of the psychoses course: a nuclear SAP type; a borderline SAP variation with phasic-recurrent course; SAP with progredient variation (schizoaffective variation of schizophrenia). The patients were examined both during the attack and remission. A rate of serotonine uptake (Vmax) in blood platelets, a specific imipramine binding (Bmax) and the level of serotonin in blood platelets were evaluated. It was found that dynamics of both Vmax and the level of serotonin in different SAP types were different, that was related to clinical and biological SAP heterogeneity. A tendency to decreasing of serotonin system functional activity was found in progredient SAP variations, especially during the remission, which was of low quality in these cases. On the contrary, in the borderline variations the indices of the decreased function of serotonin system corresponded well to those of acute psychosis. In nuclear type - a type with the most favourable course of psychosis - any significant changes weren't revealed as compared with the normal parameters.

(PDF emailed within 1 workday: $29.90)

Accession: 011125637

Download citation: RISBibTeXText


Related references

Specific aspects of thrombocyte system of serotonin in patients with different manifestations of schizoaffective psychosis. Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova 100(5): 50-54, 2000

Peculiarities of EEG dynamics in cognitive activity demanding persistent attention in patients with schizophrenia and schizoaffective psychosis and their relatives. Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova 105(8): 41-46, 2005

Serotonin receptors in platelets of bipolar and schizoaffective patients: effect of lithium treatment. Psychopharmacology 170(2): 115-123, 2003

Schizoaffective psychosis and the lithium therapy of patients suffering from schizoaffective schizophrenia. Zhurnal Nevropatologii i Psikhiatrii Imeni S.S. Korsakova 75(9): 1406-1408, 1975

Schizoaffective psychosis and the lithium therapy of patients with schizoaffective schizophrenia. Zhurnal Nevropatologii i Psikhiatrii Imeni S S Korsakova 75(9): 1406-1408, 1975

Autonomic regulation of the cardiovascular system in patients with schizoaffective psychosis. Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova 95(6): 81-83, 1995

Serotonin content in blood platelets and clinical course and laboratory parameters of the disease in patients with rheumatoid arthritis. Reumatologia (Warsaw) 36(3): 260-267, 1998

Decreased uptake of 3H-serotonin and endogenous content of serotonin in blood platelets in hypertensive patients. Hypertension 6(4): 568-573, 1984

Decreased uptake of tritium labeled serotonin and endogenous content of serotonin in blood platelets in hypertensive patients. Hypertension (Dallas) 6(4): 568-573, 1984

Assessment of blood platelets as a model for central nervous system response comparative effects of caffeine on 5 hydroxy tryptamine uptake and release mechanisms in rat platelets and rat brain serotonin neurons. Life Sciences 33(12): 1149-1156, 1983

Transport of serotonin by blood platelets: a pump-leak system. American Journal of Physiology 220(1): 283-288, 1971

Clinical and nosological approach to diagnosis of schizoaffective psychosis. Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova 102(9): 4-8, 2002

Human blood platelet serotonin studied in vitro: endogenous serotonin may stimulate thrombin-induced serotonin release in stored platelets. Platelets 7(1-2): 53-57, 1996

Clinical manifestations and function of the blood circulation system in elderly patients with rheumatism. Sovetskaia Meditsina: 70-74, 1976

Clinical analysis and follow-up study on 100 cases of schizoaffective psychosis. Zhonghua Shen Jing Jing Shen Ke Za Zhi 17(1): 43-45, 1984