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Piperacillin with and without tazobactam against extended-spectrum beta-lactamase-producing Pseudomonas aeruginosa in a rat thigh abscess model

Piperacillin with and without tazobactam against extended-spectrum beta-lactamase-producing Pseudomonas aeruginosa in a rat thigh abscess model

ChemoTherapy 47(4): 292-296

Background: We compared the antibacterial effect of piperacillin, piperacillin-tazobactam and imipenem in a paired rat thigh abscess model. Methods: Two abscesses were provoked in the thighs of rats, one on the right with an extended-spectrum beta-lactamase (OXA-14)-producing Pseudomonas aeruginosa (Ps-162) and the other on the left thigh with a control strain. Results: The colony counts from the abscesses in log 10 colony-forming units per gram (mean+-SD) in the imipenem group were 2.78+-1.71 and 3.19+-1.66, in the piperacillin-tazobactam group 4.36+-0.23 and 2.44+-1.97, and in the piperacillin group 4.44+-0.21 and 3.71+-0.99 for Ps-162 and the control strain, respectively. The mean colony counts were significantly different (p<0.05) between Ps-162 and the control strain in the piperacillin and piperacillin-tazobactam groups. Conclusion: These data showed that piperacillin and piperacillin-tazobactam were significantly less effective against extended-spectrum beta-lactamase-producing P. aeruginosa, while imipenem was equally effective against both Ps-162 and the control strain in this abscess model.

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Accession: 011155221

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PMID: 11399866

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