+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Piperacillin with and without tazobactam against extended-spectrum beta-lactamase-producing Pseudomonas aeruginosa in a rat thigh abscess model



Piperacillin with and without tazobactam against extended-spectrum beta-lactamase-producing Pseudomonas aeruginosa in a rat thigh abscess model



ChemoTherapy 47(4): 292-296



Background: We compared the antibacterial effect of piperacillin, piperacillin-tazobactam and imipenem in a paired rat thigh abscess model. Methods: Two abscesses were provoked in the thighs of rats, one on the right with an extended-spectrum beta-lactamase (OXA-14)-producing Pseudomonas aeruginosa (Ps-162) and the other on the left thigh with a control strain. Results: The colony counts from the abscesses in log 10 colony-forming units per gram (mean+-SD) in the imipenem group were 2.78+-1.71 and 3.19+-1.66, in the piperacillin-tazobactam group 4.36+-0.23 and 2.44+-1.97, and in the piperacillin group 4.44+-0.21 and 3.71+-0.99 for Ps-162 and the control strain, respectively. The mean colony counts were significantly different (p<0.05) between Ps-162 and the control strain in the piperacillin and piperacillin-tazobactam groups. Conclusion: These data showed that piperacillin and piperacillin-tazobactam were significantly less effective against extended-spectrum beta-lactamase-producing P. aeruginosa, while imipenem was equally effective against both Ps-162 and the control strain in this abscess model.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 011155221

Download citation: RISBibTeXText

PMID: 11399866


Related references

Piperacillin with and without Tazobactam against Extended-Spectrum Beta-Lactamase-Producing Pseudomonas aeruginosa in a Rat Thigh Abscess Model. Chemotherapy 47(4): 292-296, 2001

Efficacy of piperacillin-tazobactam in intraabdominal abscess due to a Klebsiella pneumoniae producing an extended-spectrum beta-lactamase. Abstracts of the Interscience Conference on Antimicrobial Agents & Chemotherapy 35: 32, 1995

Comparative assessment of inoculum effects on the antimicrobial activity of amoxycillin-clavulanate and piperacillin-tazobactam with extended-spectrum beta-lactamase-producing and extended-spectrum beta-lactamase-non-producing Escherichia coli isolates. Clinical Microbiology and Infection 16(2): 132-136, 2010

Superior effect of tazobactam/piperacillin compared to piperacillin on beta-lactamase-producing Pseudomonas aeruginosa. ChemoTherapy 43(3): 171-178, 1997

In vitro susceptibility of multi-drug resistant Pseudomonas aeruginosa and extended-spectrum β-lactamase-producing Klebsiella pneumoniae isolated from clinical specimens at Bugando Medical Centre, Tanzania to Piperacillin-Tazobactam. Tanzania Journal of Health Research 16(1): 54-57, 2014

Conjugative resistance to tazobactam plus piperacillin among extended-spectrum beta-lactamase-producing nosocomial Klebsiella pneumoniae. Scandinavian Journal of Infectious Diseases 33(7): 512-515, 2001

Cefepime, piperacillin-tazobactam, and the inoculum effect in tests with extended-spectrum beta-lactamase-producing Enterobacteriaceae. Antimicrobial Agents and ChemoTherapy 45(12): 3548-3554, 2001

Comparative activity of piperacillin/tazobactam against clinical isolates of extended-spectrum beta-lactamase-producing Enterobacteriaceae. ChemoTherapy 44(6): 377-384, 1998

Superior Effect of Tazobactam/ Piperacillin Compared to Piperacillin on -Lactamase-Producing Pseudomonas aeruginosa. Chemotherapy 43(3): 171-178, 1997

Pharmacodynamics of intermittent and continuous infusion piperacillin/tazobactam and cefepime against extended-spectrum beta-lactamase-producing organisms. International Journal of Antimicrobial Agents 26(2): 114-119, 2005

Empiric Piperacillin-Tazobactam versus Carbapenems in the Treatment of Bacteraemia Due to Extended-Spectrum Beta-Lactamase-Producing Enterobacteriaceae. Plos one 11(4): E0153696, 2016

Impact of the MIC of Piperacillin-Tazobactam on the Outcome of Patients with Bacteremia Due to Extended-Spectrum-beta-Lactamase-Producing Escherichia coli. 2013

In vitro synergy studies based on tazobactam/piperacillin against clinical isolates of metallo-beta-lactamase-producing Pseudomonas aeruginosa. Journal of Antimicrobial ChemoTherapy 64(5): 1115-1116, 2009

Pharmacodynamics of intermittent piperacillin/tazobactam and cefepime against extended-spectrum beta-lactamase producing organisms using Monte Carlo simulation. Pharmacotherapy 23(10): 1348-1349, 2003

Antibiotic policy and prescribing strategies for therapy of extended-spectrum beta-lactamase-producing Enterobacteriaceae: the role of piperacillin-tazobactam. Clinical Microbiology and Infection 14(Suppl. 1): 181-184, 2008