+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Poor serologic responses five to seven years after immunization with high and standard titer measles vaccines



Poor serologic responses five to seven years after immunization with high and standard titer measles vaccines



Pediatric Infectious Disease Journal 18(1): 53-57



Background. Few data exist on the persistence of measles antibodies after vaccination of West African infants. Therefore we examined measles antibody titers 5 to 7 years after children in rural Senegal had received high titer Edmonston-Zagreb (EZ-HT), high titer Schwarz (SW-HT) or standard titer Schwarz (SW-STD) measles vaccines in infancy. Methods. Children had received either high titer vaccines at 5 months of age or standard titer at 10 months of age. Finger prick blood samples were tested for measles antibody 5 to 7 years later by the hemagglutinin inhibition test. Results. Persistence of antibody after high titer vaccines was poor with the result that 39 and 50% of the EZ-HT and the SW-HT groups had low titers of hemagglutinin inhibition measles antibodies (ltoreq125 mIU/ml). Nineteen percent of the children in the SW-STD group had low titers which is a lower prevalence than in the high titer groups (relative risk (95% confidence intervals), 0.05 (0.28 to 0.88) vs. EZ-HT; relative risk, 0.38 (0.22 to 0.66) vs. SW-HT). Geometric mean (95% confidence interval) antibody titers in children with detectable values were 616 (435 to 871) in the EZ-HT, 1106 (616 to 1866) in the SW-HT and 1271 (871 to 1741) MIU/ml in the SW-STD groups, respectively. Multivariant regression analysis showed that mean titers were 2.00 (1.03 to 3.89) times higher for children with low prevaccination antibody titers (ltoreq125 mIU/ml) and 3.06 (1.90 to 4.94) times higher if blood was collected in the rainy season. Interpretation. Given the rapid decline in anti body titers over a 5- to 6-year period in an area where measles vaccine coverage was high, it seems likely that multiple dose immunization schedules will be needed in the future to maintain protective antibody concentrations (>125 mIU/ml) in West Africa. The role of subclinical boosting by exposure to natural measles and the possible role of malaria, which increases immunoglobulin turnover, in influencing long term antibody persistence after vaccination deserve further investigation.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 011167902

Download citation: RISBibTeXText

PMID: 9951981


Related references

Functional antibody responses in children receiving standard or high-titer measles vaccines. Abstracts of the Interscience Conference on Antimicrobial Agents & Chemotherapy 36: 174, 1996

Immunologic parameters 2 years after high-titer measles immunization in Peruvian children. Journal of Infectious Diseases 168(5): 1097-1104, 1993

Immunologic Parameters 2 Years after High-Titer Measles Immunization in Peruvian Childre. Journal of Infectious Diseases 168(5): 1097-1104, 1993

Divergent mortality for male and female recipients of low-titer and high-titer measles vaccines in rural Senegal. American Journal of Epidemiology 138(9): 746-755, 1993

Randomized Trials Comparing Inactivated Vaccine After Medium- or High-titer Measles Vaccine With Standard Titer Measles Vaccine After Inactivated Vaccine: A Meta-analysis. Pediatric Infectious Disease Journal 35(11): 1232-1241, 2016

Increased mortality after high titer measles vaccines. The Pediatric Infectious Disease Journal 12(6): 462-465, 1993

Measles vaccination: III. Serologic responses to immunization with purified hemagglutinin. Acta Paediat Scand 54(6): 581-586, 1965

Measles vaccination. 3. Serologic responses to immunization with purified hemagglutinin. Acta Paediatrica Scandinavica 54(6): 581-586, 1965

Measles virus antibody responses in children randomly assigned to receive standard-titer edmonston-zagreb measles vaccine at 4.5 and 9 months of age, 9 months of age, or 9 and 18 months of age. Journal of Infectious Diseases 210(5): 693-700, 2014

Increased mortality after high titer measles vaccines: too much of a good thing. Pediatric Infectious Disease Journal 12(6): 462-465, 1993

Aerosolized measles and measles-rubella vaccines induce better measles antibody booster responses than injected vaccines: randomized trials in Mexican schoolchildren. Bulletin of the World Health Organization 80(10): 806-812, 2002

Comparison of high titer Edmonston-Zagreb, Biken-CAM and Schwarz measles vaccines in Peruvian infants. Pediatric Infectious Disease Journal 11(10): 822-827, 1992

Immunization With Live Attenuated Measles Virus Vaccines: Five Years' Experience. Archiv für die Gesamte Virusforschung 16: 222-230, 1965

Reactions and serologic responses after administration of inactivated monovalent influenza A/swine virus vaccines. II. Immunization of children with influenza A/New Jersey/X-53 virus vaccines. Journal of Infectious Diseases 136 Suppl: S609-S611, 1977

Reactions and serologic responses after administration of inactivated monovalent influenza A/swine virus vaccines. I. Immunization of children and adults with influenza A/Shope virus vaccines. Journal of Infectious Diseases 136 Suppl: S604-S608, 1977