+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Postnatal development of nitric oxide synthase expression in the mouse superior colliculus



Postnatal development of nitric oxide synthase expression in the mouse superior colliculus



Journal of Comparative Neurology 427(4): 581-592



Since nitric oxide has a role in the refinement of the retinal projection to the superior colliculus (SC), we studied the onset of neuronal nitric oxide synthase (nNOS) expression in the mouse SC in order to compare its development with that of the refinement process. Sections from animals at ages P1, P5, P8, P11, P15, and P21 and adults were examined with nicotinamide adenine dinucleotide phosphate diaphorase (NADPHd) histochemistry or immunocytochemistry using an antibody directed against nNOS. At all ages there was a wedge of labeled neurons in the dorsolateral periaqueductal gray extending into the deep layers of the SC. At P1 there was also a single superficial band of labeled neurons within the region that will become the intermediate gray layer (IGL). By P5, labeled neurons were also seen in what will become the superficial gray layer. There was a ventral to dorsal progression in nNOS expression with substantial changes in the numbers of labeled neurons in the different laminae between P5 and adulthood. The number of labeled neurons in the IGL peaked at P15, whereas in the superficial layers the numbers continued to increase through P21 and then declined in adults. At all ages these neurons represented a variety of morphological cell types. The onset of nNOS expression in the different laminae is earlier than has been reported in studies using NADPHd as a marker for nNOS. The temporal and spatial patterns of nNOS expression reported here match more closely the time course of pathway refinement in the SC, providing additional evidence for the involvement of nitric oxide in this process.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 011174378

Download citation: RISBibTeXText

PMID: 11056465

DOI: 10.1002/1096-9861(20001127)427:4<581::aid-cne6>3.0.co;2-m


Related references

Pre- and postnatal expression of amino acid neurotransmitters, calcium binding proteins, and nitric oxide synthase in the developing superior colliculus. Progress in Brain Research 108: 313-332, 1996

Patterns of nitric oxide synthase expression in the developing superior colliculus. Revista Brasileira de Biologia 56 Su 1 Pt 1: 113-122, 1996

Immunohistochemical investigation of the vomeronasal organ. Nitric oxide synthase expression in the mouse during postnatal development. Neuroscience Letters 269(1): 5-8, 1999

Immunohistochemical investigation of the vomeronasal organ. Nitric oxide synthase expression in the mouse during postnatal development. Neuroscience Letters 269(1): 5-8, 1999

Nitric oxide synthase is expressed early in the prenatal development of the cat superior colliculus. Society for Neuroscience Abstracts 21(1-3): 817, 1995

Cholinergic fiber patches in the mouse superior colliculus develop normally in e,n nitric oxide synthase knockout mice. FASEB Journal 12(5): A757, 1998

Maturation of multisensory integration in the superior colliculus: expression of nitric oxide synthase and neurofilament SMI-32. Brain Research 1242: 45-53, 2008

Expression of neuronal nitric oxide synthase in the developing superficial layers of the rat superior colliculus. Brazilian Journal of Medical and Biological Research 37(6): 869-877, 2004

Cholinergic fiber patches in the mouse superior colliculus develop normally in nitric oxide synthase gene deficient mice. Society for Neuroscience Abstracts 23(1-2): 1159, 1997

Nitric oxide synthase expression in the opossum superior colliculus: a histochemical, immunohistochemical and biochemical study. Brain Behavior and Evolution 54(6): 303-313, 1999

Nitric Oxide Synthase Expression in the Opossum Superior Colliculus: A Histochemical, Immunohistochemical and Biochemical Study. Brain, Behavior and Evolution 54(6): 303-313, 1999

Prenatal and postnatal expression of nitric oxide in the developing kitten superior colliculus revealed with NADPH diaphorase histochemistry. Visual Neuroscience 18(1): 43-54, 2001

Inhibition of nitric oxide synthase fails to disrupt the development of cholinergic fiber patches in the rat superior colliculus. Developmental Neuroscience 19(3): 260-273, 1997

Inhibition of Nitric Oxide Synthase Fails to Disrupt the Development of Cholinergic Fiber Patches in the Rat Superior Colliculus. Developmental Neuroscience 19(3): 260-273, 1997

Late postnatal shifts of parvalbumin and nitric oxide synthase expression within the GABAergic and glutamatergic phenotypes of inferior colliculus neurons. Journal of Comparative Neurology 525(4): 868-884, 2017