+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Postnatal ontogeny and hormonal regulation of sulfotransferase SULT1B1 in male and female rats



Postnatal ontogeny and hormonal regulation of sulfotransferase SULT1B1 in male and female rats



Journal of Pharmacology and Experimental Therapeutics 290(1): 319-324



The ontogenic and hormonal regulation of a sulfotransferase, SULT1B1, was examined. Hepatic RNA was isolated from rats of various ages from 1 to 90 days. The mRNA for SULT1B1 is low for both sexes until a dramatic increase ( approximately 6-fold) occurs between 15 and 30 days of age in male rats. SULT1B1 expression then decreases to half of the maximal level by 90 days of age. The increase in SULT1B1 mRNA in female rats is less dramatic and occurs between 30 and 45 days of age. SULT1B1 mRNA expression plateaus from 45 to 90 days in female rats. Expression of SULT1B1 mRNA is comparable in adult male and female rats. RNA was isolated from hypophysectomized (HX) animals and HX animals treated with growth hormone [by either male (injection) or female (infusion) pattern], estradiol, progesterone, or testosterone. HX and HX plus growth hormone, or HX plus steroid replacement, did not alter SULT1B1 mRNA expression. Pituitary-intact rats were treated with steroidal compounds dexamethasone (DEX) and pregnenolone-16alpha-carbonitrile (PCN). Both DEX and PCN increased expression of SULT1B1 mRNA in male rats (4- and 3-fold, respectively). However, in female rats, only PCN induced SULT1B1 mRNA (2-fold), whereas DEX did not induce SULT1B1 in female rats. Analysis of SULT1B1 protein expression indicated that only when SULT1B1 mRNA was markedly increased, that is in DEX-treated male rats, was SULT1B1 protein increased. Thus, although adult male and female rats have similar SULT1B1 mRNA expressions, the patterns develop ontogenically differently. SULT1B1 is not regulated by pituitary hormones and DEX induces SULT1B1 protein in male rats.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 011174538

Download citation: RISBibTeXText

PMID: 10381794


Related references

Postnatal ontogeny of angiotensin receptors and ACE2 in male and female rats. Gender Medicine 9(1): 21-32, 2012

Regulation of sulfotransferase mRNA expression in male and female rats of various ages. Chemico-Biological Interactions 109(1-3): 299-313, 1998

Adolescence and the ontogeny of the hormonal stress response in male and female rats and mice. Neuroscience and Biobehavioral Reviews 70: 206-216, 2016

Expression of rat multidrug resistance protein 2 in male and female rats during normal and pregnenolone-16alpha-carbonitrile -induced postnatal ontogeny. Toxicology 178(3): 209-219, September 16th, 2002

Expression of rat Multidrug Resistance Protein 2 (Mrp2) in male and female rats during normal and pregnenolone-16alpha-carbonitrile (PCN)-induced postnatal ontogeny. Toxicology 178(3): 209-219, 2002

Ontogeny of GH mRNA and GH secretion in male and female rats: regulation by GH-releasing hormone. American Journal of Physiology 265(2 Pt 1): E236-E242, 1993

Hormonal regulation of female proceptivity and its influence on male sexual preference in rats. Physiology & Behavior 31(5): 679-686, 1983

The hormonal regulation of mRNA Na,K-ATPase expression in rat kidneys in postnatal ontogeny. Tsitologiia 33(11): 18-25, 1991

The characteristics of the hormonal profile of the central links in the regulation of adrenocortical function in rat postnatal ontogeny. Zhurnal Evoliutsionnoi Biokhimii i Fiziologii 27(4): 467-471, 1991

Autoradiographic study of hormonal regulation of proliferating golden hamster uterus cells during postnatal ontogeny. Biulleten' Eksperimental'noi Biologii i Meditsiny 92(9): 359-361, 1981

Tamoxifen induction of aryl sulfotransferase and hydroxysteroid sulfotransferase in male and female rat liver and intestine. Drug Metabolism and Disposition: the Biological Fate of Chemicals 31(5): 637-644, 2003

The hormonal indices of the reactivity of the central links in the hypothalamo-hypophyseal-adrenocortical system of rats during postnatal ontogeny. Zhurnal Evoliutsionnoi Biokhimii i Fiziologii 27(3): 308-313, 1991

Molecular cloning, expression, and characterization of a novel mouse liver SULT1B1 sulfotransferase. Journal of Biochemistry 124(1): 55-64, 1998

Hormonal influences during the ontogeny of maternal behavior in female rats. Journal of Comparative & Physiological Psychology 93(5): 879-898, 1979