+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Postnatal screening for thrombophilia in women with severe pregnancy complications



Postnatal screening for thrombophilia in women with severe pregnancy complications



Obstetrics & Gynecology 97(5 Part 1): 753-759



Objective: To examine the prevalence of maternal thrombophilia in women with severe preeclampsia/eclampsia, placental abruption, fetal growth restriction, and unexplained stillbirth. Methods: We studied 102 women who had pregnancy complications and 44 healthy women with uncomplicated pregnancies. All women were tested 10 weeks postpartum for mutations of factor V Leiden, methylenetetrahydrofolate reductase (MTHFR) C677T, and G20210A prothrombin gene; deficiencies of protein C, protein S, and antithrombin III; and the presence of lupus anticoagulant and anticardiolipin antibodies. We aimed to recruit 100 cases and 300 controls to detect a 10% difference in thrombophilia between the groups. However, we were able to recruit only 44 controls. Results: Abnormal thrombophilia screen was found in 54 women with pregnancy complications (53%) and in 17 women (39%) with normal pregnancies (odds ratio (OR) 1.8; 95% confidence interval (CI) 0.87, 3.67). Mutations encoding for factor V Leiden, G20210A prothrombin gene, and MTHFR C677T (homozygous) were identified in 18% of women with complications compared with 16% of controls (OR 1.1; 95% CI 0.44, 2.94). Activated protein C resistance, not due to factor V Leiden mutation, was the most common thrombophilic defect, found in 26% of women with pregnancy complications compared with 18% of controls (OR 1.5; 95% CI 0.63, 3.73). Twenty women with complications (20%) had multiple thrombophilic defects compared with four controls (9%) (OR 2.4; 95% CI 0.78, 7.61). Conclusion: In our cohort of women with pregnancy complications, maternal thrombophilia was less common than previously thought, and multiple thrombophilias were not a major additional risk factor.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 011174563

Download citation: RISBibTeXText

PMID: 11339929

DOI: 10.1016/s0029-7844(01)01190-5


Related references

Postnatal Screening for Thrombophilia in Women With Severe Pregnancy Complications. Obstetrics & Gynecology 97(5): 753-759, 2001

Pathologic features of the placenta in women with severe pregnancy complications and thrombophilia. Obstetrics & Gynecology 98(6): 1041-1044, 2001

Pathologic features of the placenta in women with severe pregnancy complications and thrombophilia. Obstetrics and Gynecology 98(6): 1041-1044, 2001

Placental pathologic features of women with severe pregnancy complications and thrombophilia. American Journal of Obstetrics & Gynecology 182(1 Part 2): S163, 2000

Pathologic Features of the Placenta in Women With Severe Pregnancy Complications and Thrombophilia. Obstetrics & Gynecology 98(6): 1041-1044, 2001

Low molecular weight heparin versus no treatment in women with previous severe pregnancy complications and placental findings without thrombophilia. Blood Coagulation and Fibrinolysis 22(2): 123-126, 2011

Low molecular weight heparin treatment during subsequent pregnancies of women with inherited thrombophilia and previous severe pregnancy complications. Journal of Maternal-Fetal and Neonatal Medicine 24(8): 1042-1045, 2011

Thrombophilia in women with pregnancy-associated complications: fetal loss and pregnancy-related venous thromboembolism. Gynecologic and Obstetric Investigation 69(4): 233-238, 2010

Severe third-trimester pregnancy complications are associated with inherited thrombophilia. American Journal of Obstetrics & Gynecology 185(6 Suppl.): S118, 2001

Pregnancy complications in women with inherited thrombophilia. Archives of Gynecology and Obstetrics 274(3): 125-129, 2006

Antithrombotic prophylaxis for women with thrombophilia and pregnancy complications--No. Journal of Thrombosis and Haemostasis 1(10): 2073-2074, 2003

Antithrombotic prophylaxis for women with thrombophilia and pregnancy complications. Journal of Thrombosis and Haemostasis 2(7): 1182-1192, 2004

Antithrombotic prophylaxis for women with thrombophilia and pregnancy complications--Yes. Journal of Thrombosis and Haemostasis 1(10): 2070-2072, 2003

Antithrombotic prophylaxis in women with thrombophilia and pregnancy complications. Journal of Thrombosis and Haemostasis 2(7): 1190-1192, 2004

Effects of enoxaparin on late pregnancy complications and neonatal outcome in women with recurrent pregnancy loss and thrombophilia: results from the Live-Enox study. Fertility and Sterility 84(3): 770-773, 2005