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Postoperative systemic corticosteroid treatment and Molteno implant surgery: A randomized clinical trial

Postoperative systemic corticosteroid treatment and Molteno implant surgery: A randomized clinical trial

Acta Ophthalmologica Scandinavica 77(1): 50-56

Purpose: To determine whether it is possible to improve the surgical success of Molteno implantation by causing a general suppression of collagen synthesis with postoperative oral prednisolone. Methods: Twenty-two patients requiring single stage, single-plate Molteno implantation were randomized, into two study groups: the control group A and the systemic prednisolone treatment group B. Serum markers of collagen metabolism were monitored. Results: A successful outcome at the end of the 6-month follow-up, defined as final IOP gtoreq6 mmHg and ltoreq22 mmHg with less or equal number of antiglaucoma medication as preoperatively and no additional surgery was achieved in 9 of 11 (82%) patients of group A and in 5 of 10 (50%) patients of group B (p = 0.18). There was a statistically significant decrease in serum markers of collagen synthesis in the group B but not in the group A. Conclusion: The serum markers indicated a systemic effect of oral prednisolone on collagen synthesis in group B but it did not improve the surgical outcome as compared to the controls.

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Accession: 011174949

Download citation: RISBibTeXText

PMID: 10071149

DOI: 10.1034/j.1600-0420.1999.770112.x

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