+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Preperimetric glaucoma diagnosis by confocal scanning laser tomography of the optic disc



Preperimetric glaucoma diagnosis by confocal scanning laser tomography of the optic disc



British Journal of Ophthalmology 83(3): 299-304



Aim-To evaluate the ability of confocal scanning laser tomography of the optic nerve head to detect glaucomatous optic nerve damage in ocular hypertensive eyes without visual field defects. Methods-The study included 50 normal subjects, 61 glaucoma patients with glaucomatous changes in the optic disc and visual field, and 102 "preperimetric" patients with increased intraocular pressure, normal visual fields, and glaucomatous appearance of the optic disc as evaluated on colour stereo optic disc photographs. For all individuals, confocal scanning laser tomographs of the optic nerve head were taken using the Heidelberg retina tomograph (HRT; software 2.01). Results-Almost all investigated HRT variables varied significantly (p<0.05) between the normal eyes and preperimetric glaucoma eyes with pronounced overlap between the two study groups. Corresponding to the overlap, sensitivity and specificity values were relatively low when HRT variables were taken to differentiate between normal and preperimetric glaucoma eyes. At a given specificity of 95% highest sensitivities were found for the variables "rim area in the superior disc sector" (24.8%), "nerve fibre layer thickness in the inferior disc sector" (26.5%), and "rim volume in the superior disc sector" (25.5%). A multivariate approach increased sensitivity to 42.2% at a given specificity of 95%. For the glaucoma group highest sensitivity values were reached by rim volume in the superior disc sector (73.8%) and rim area (72.1%); the multivariate approach reached 83.6%. Conclusions-Owing to pronounced overlapping between the groups, confocal scanning laser tomography of the optic nerve head has relatively low diagnostic power to differentiate between normal eyes and preperimetric glaucoma eyes. One of the reasons may be the biological interindividual variability of quantitative optic disc variables.

(PDF emailed within 0-6 h: $19.90)

Accession: 011189688

Download citation: RISBibTeXText

PMID: 10365037

DOI: 10.1136/bjo.83.3.299


Related references

Optic disc progression in glaucoma: comparison of confocal scanning laser tomography to optic disc photographs in a prospective study. Investigative Ophthalmology and Visual Science 50(4): 1682-1691, 2008

Confocal scanning laser tomography of the optic nerve head of glaucoma patients: inter-correlation of disc parameters. Ghana Medical Journal 43(4): 150-156, 2009

Evaluation of the influence of tilt of optic disc on the measurement of optic disc variables obtained by optical coherence tomography and confocal scanning laser ophthalmoscopy. Journal of Glaucoma 14(3): 210-214, 2005

Confocal laser scanning tomography (HRT) in diagnosis and monitoring glaucomatous optic nerve damage in primary open angle glaucoma. Klinika Oczna 106(3): 312-317, 2004

Optic disc and visual field changes in a prospective longitudinal study of patients with glaucoma: comparison of scanning laser tomography with conventional perimetry and optic disc photography. Archives of Ophthalmology 119(10): 1492-1499, 2001

Correlation of visual field with scanning confocal laser optic disc measurements in glaucoma. Archives of Ophthalmology 113(9): 1191-1194, 1995

Comparability of three-dimensional optic disc imaging with different techniques. A study with confocal scanning laser tomography and raster tomography. Acta Ophthalmologica Scandinavica 78(1): 9-13, 2000

Detection of glaucomatous optic disc hemorrhages by confocal scanning laser tomography. Archives of Ophthalmology 115(6): 800-801, 1997

Quantitative and objective follow-up of optic disc swelling with confocal scanning laser tomography. Investigative Ophthalmology & Visual Science 38(4 PART 1-2): S7, 1997

Optic disc morphometry correlated with confocal laser scanning Doppler flowmetry measurements in normal-pressure glaucoma. Journal of Glaucoma 12(3): 260-265, 2003

Optic disc surface compliance testing using confocal scanning laser tomography in the normal monkey eye. Journal of Glaucoma 10(5): 369-382, 2001

Inter-observer variability of optic disc parameters measured by confocal scanning laser tomography. IOVS 40(4): S72, March 15, 1999

Correlations between retinal thickness analyzer (RTA) and confocal scanning laser tomography (HRT) in optic disc analysis. Archivos de la Sociedad Espanola de Oftalmologia 79(1): 21-25, 2004

Optic disc measurements in myopia with optical coherence tomography and confocal scanning laser ophthalmoscopy. Investigative Ophthalmology and Visual Science 48(7): 3178-3183, 2007

Comparing neural networks and linear discriminant functions for glaucoma detection using confocal scanning laser ophthalmoscopy of the optic disc. Investigative Ophthalmology and Visual Science 43(11): 3444-3454, 2002