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Prepro-hypocretin (prepro-orexin) expression is unaffected by short-term sleep deprivation in rats and mice

Prepro-hypocretin (prepro-orexin) expression is unaffected by short-term sleep deprivation in rats and mice

Sleep 23(7): 867-874

ISSN/ISBN: 0161-8105

PMID: 11083595

DOI: 10.1093/sleep/23.7.1a

The hypocretin/orexin ligand-receptor system has recently been implicated in the sleep disorder narcolepsy. During the dark (active) period, null mutants of the prepro-orexin (prepro-hypocretin) gene have cataplectic attacks and increased levels of both rapid eye movement (REM) and non-REM (NREM) sleep.

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Accession: 011189711

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