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Prevalence and clinical features of hepatitis delta virus infection in the Miyako Islands, Okinawa, Japan



Prevalence and clinical features of hepatitis delta virus infection in the Miyako Islands, Okinawa, Japan



Journal of Gastroenterology 33(6): 850-854



The aims of this study were two-fold: (1) to determine the prevalence and clinical features of hepatitis delta virus (HDV) infection among subjects positive for hepatitis B surface antigen (HBsAg) living in the Miyako Islands, Okinawa Prefecture, Japan, and (2) to clarify the relationship between HDV-RNA level and severity of HDV-related liver disease. One hundred and ninety-nine HBsAg-positive subjects (123 asymptomatic carriers (ASCs), 3 patients with acute hepatitis (AH), 50 patients with chronic hepatitis (CH), 15 patients with liver cirrhosis (LC), and 8 patients with hepatocellular carcinoma (HCC)) were tested for antibody to HDV (anti-HDV) by radioimmunoassay. Anti-HDV-positive individuals were examined to determine semi-quantified HDV-RNA level by polymerase chain reaction (PCR). The overall prevalence of anti-HDV among the 199 subjects was 21.1%. The positivity rate tended to increase with age or the severity of the underlying liver disease: anti-HDV-positive rates were 10.6% (13/123) in ASCs, 32.0% (16/50) in patients with CH, 40.0% (6/15) in patients with LC, and 87.5% (7/8) in patients with HCC. None of the patients with AH were positive for anti-HDV. There was no correlation between semi-quantified serum HDV-RNA levels and the severity of chronic liver disease in patients positive for anti-HDV. The present study showed the local spread of HDV infection in the Miyako Islands, Okinawa, Japan. Although the anti-HDV positivity rate tended to increase with the severity of the underlying liver disease, the severity of HDV-related liver disease did not correlate with the semi-quantified serum HDV-RNA level.

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Accession: 011192278

Download citation: RISBibTeXText

PMID: 9853558

DOI: 10.1007/s005350050186


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