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Preventive effects of sulphasalazine on colorectal carcinogenesis in mice with ulcerative colitis



Preventive effects of sulphasalazine on colorectal carcinogenesis in mice with ulcerative colitis



In Vivo 14(3): 463-466



Sulphasalazine has been used in the treatment of ulcerative colitis and is known to be a prodrug and split into sulphapyridine and 5-aminosalicylic acid by bacteria in the colon. An increased incidence of colorectal carcinoma is known to occur in patients with ulcerative colitis, which displays a recurrence-remission cycle on colorectal mucosa, i.e., the ulceration and regeneration periods of the colorectal mucosa. Repeated mucosal necrosis-regeneration sequence in chronic ulcerative colitis induced with 3 % dextran sulfate sodium led to colorectal carcinogenesis in azoxymethane-pretreated mice. Additive treatment with sulphasalazine normalized the enlarged organs, i.e. liver, spleen and kidney and anemia and leucocytosis induced with 3 % dextran sulfate sodium resulted in the reduction of tumorous regions with high-grade dysplasia.

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Accession: 011196536

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PMID: 10904883



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