+ Translate

Prognostic factors for the development of rheumatoid arthritis and other connective tissue diseases in patients with palindromic rheumatism

, : Prognostic factors for the development of rheumatoid arthritis and other connective tissue diseases in patients with palindromic rheumatism. Journal of Rheumatology 26(3): 540-545

Objective. Palindromic rheumatism is characterized by attacks of acute arthritis of short duration. In the long term, a substantial proportion of patients will develop rheumatoid arthritis (RA) or other connective tissue diseases, but the determinants of subsequent chronic disease have not been adequately established. We identify clinical prognostic factors for the development of RA and other connective tissue diseases in patients with palindromic rheumatism in a retrospective cohort study. Methods. The medical records of 4900 patients with arthritis referred from 1986 to 1996 to 3 rheumatologists at an academic center were reviewed. One hundred sixty patients were diagnosed as having palindromic rheumatism. After review, 127 complied with diagnostic criteria for palindromic rheumatism. Disease duration was estimated as time of first attack until the last consultation, or the development of RA or other connective tissue disease. Survival analysis including Cox regression was used to identify clinical variables associated with the risk of developing RA or other connective tissue disease, adjusting for varying disease duration. Results. Sixty-five percent of the patients were female. Age at onset was 40 +- 12 years. Mean disease duration was 6 +- 6 years, and mean followup by the rheumatologists was 40 +- 45 months. Joints more frequently affected were wrist, knee, and metacarpophalangeal. Forty-three patients (34%) subsequently developed a connective tissue disease including 36 (28%) RA, 3 (2%) systemic lupus erythematosus, and 4 (3%) other connective tissue diseases. In the final Cox regression model the hazard ratio for development of a connective tissue disease in the presence of a positive rheumatoid factor (RF) was 2.9 (p = 0.002), for proximal interphalangeal (PIP) joint involvement 2.4 (p = 0.02), for wrist involvement 2.5 (p = 0.05), for female sex 2.2 (p = 0.05), and for age at onset 1.03 (per year) (p = 0.001). Female patients with positive RF and involvement of the hands had an 8-fold risk of developing disease, compared with patients with one or fewer of these features. Conclusion. Positive RF and early involvement of the wrist and PIP joints predict the subsequent development of RA or other connective tissue disease in patients with palindromic rheumatism, and identify a group of patients at increased risk.

(PDF 0-2 workdays service)

Order PDF Full Text


Click here to order any other PDF Full Text

Accession: 011206164

PMID: 10090159

PDF Full Text: Submit

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Other references

Lungu, I.; Podeanu, P.; Ionescu, R. V.; Et Al., 1960: The dynamics of soil temperature in the sandy soils of Timburesti.. Three-year measurements at different depths down to 320 cm, made three times a day, indicated that the sandy soils in question were subject to considerable cooling and warming to depths of 70 cm.

Nakayama, E.; Uenaka, A., 1985: Effect of in vivo administration of Lyt antibodies. Lyt phenotype of T cells in lymphoid tissues and blocking of tumor rejection. After transplantation of B6RV2 leukemia, initial tumor growth was followed by tumor regression in B6 (CB6F1) female, but not male, mice. This indicated that H-Y antigen is involved in B6RV2 rejection by syngeneic female recipient mice. In the case...

Bassi R.; Hinz U.; Barbato R., 1985: The role of the light harvesting complex and photosystem ii in thylakoid stacking in the chlorina f 2 barley mutant. The stacking behaviour of isolated thylakoids of the chlorophyll b-less barley mutant chlorina-f2, which is highly deficient in the light harvesting complex (LHCII), was investigated using electron microscopy. Pre-treatment with EDTA prevented thy...

Konishi F.; Muto T.; Kamiya J.; Sawada T.; Sugihara K.; Morioka Y.; Bussey H.J.R.; Morson B.C., 1984: Histopathologic comparison of colorectal adenomas in english and japanese patients. Histopathologic comparison of colorectal adenomas removed at St. Mark's Hospital, London, England, and those removed at the University of Tokyo, Japan was performed. There were 1242 lesions in the St. Mark's series and 310 in the Univers...

Anonymous, 1980: Annual review of the Tanzania coffee industry: 1979. Coffee is of vital importance to the economic and social development of Tanzania and was the country's main foreign exchange earner in 1978. The report discusses coffee's role in the national economy, and then examines in detail, for 197...

Simões, R.Conceição.; Rocha, B.Anderson.Matias.; Bezerra, M.Julia.Barbosa.; Barroso-Neto, I.Liberato.; Pereira-Junior, F.Nascimento.; da Mata Moura, R.; do Nascimento, K.Santiago.; Nagano, C.Shiniti.; Delatorre, P.; de Freitas Pires, A.; Assreuy, A.Maria.Sampaio.; Sampaio, A.Holanda.; Cavada, B.Sousa., 2012: Protein crystal content analysis by mass spectrometry and preliminary X-ray diffraction of a lectin from Canavalia grandiflora seeds with modulatory role in inflammation. Lectins are a family of proteins capable of deciphering the glycan code. Several authors have published works about crystallization and mass spectrometry analyses of ConA-like lectins. However, mass spectrometry has never been used to characterize...

Ali, Syed Sultan; Jafri, S. J. H.; Butt, M. A., 1993: Estimation of heterosis and heterobeltiosis for some allogamic traits in Oryza sativa L. Pakistan Journal of Scientific & Industrial Research 36(6-7): 281-282

Korngreen, Dorit; Conway, Brian H.; Orlov-Labkovsky, Olga, 2011: Permo-Triassic P/T transition at the coastal plain in Israel David 1 Borehole, north Arabian Plate margin. Record - Geological Survey of Western Australia: 81

Costin A. B., 1962: The soils of the high plains. "The soils of the high plains are mainly alpine humus soils, with lithosols, bog peats and humified peats. There are also smaller occurrences of acid fen peats, acid marsh soils, gley podzols, and snowpatch meadow soils. . . . Certain soil pr...

Mulholland, D.A.; Bryars, J.H.; McKinstry, S., 1995: Traumatic intraorbital aerocele with pneumocephalus. British Journal of Ophthalmology 79(5): 504-505