+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Prognostic role of p21WAF1 expression in areca quid chewing and smoking-associated oral squamous cell carcinoma in Taiwan



Prognostic role of p21WAF1 expression in areca quid chewing and smoking-associated oral squamous cell carcinoma in Taiwan



Journal of Oral Pathology & Medicine 31(1): 16-22



Background: Alterations in p21WAF1 protein expression have been observed in a wide variety of human cancers by immunohistochemistry, and both decreased and increased levels of p21WAF1 protein expression have been shown to correlate with poor prognosis. Method: To examine the relation between p21WAF1 protein expression and prognosis in oral squamous cell carcinomas (SCCs), we performed an immunohistochemical study with antip21WAF1 antibody on 43 oral SCCs. Immunostaining results were then correlated with p53 protein levels, clinicopathological parameters of the tumors and overall patient survival. Results: Of the 43 patients, 31 (72%) had tumors with positive p21WAF1 nuclear staining and 27 (63%) had tumors with p53 nuclear staining. There was no significant correlation between p21WAF1 and p53 protein expressions and both mutant p53-containing oral SCCs overexpressed p21WAF1 protein. In addition, no significant correlation was found between the p21WAF1 expression and the patients' age, sex, oral habit, cancer location, or primary tumor TNM status at the time of initial presentation. The Kaplan-Meier analysis showed a significant correlation between p21WAF1 protein overexpression and poor patient overall survival (P=0.049). When p53 and p21WAF1 were evaluated together, the 5-year overall survival was lowest in p53(+)-p21WAF1(+) patients and highest in p53(-)-p21WAF1(-) patients (P=0.057). Conclusion: Combined evaluation of p21WAF1 and p53 expressions may be useful in estimating the prognosis of patients with oral SCCs in Taiwan.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 011206614

Download citation: RISBibTeXText

PMID: 11896818

DOI: 10.1046/j.0904-2512.2001.10055.x


Related references

Prognostic role of c-Jun activation in patients with areca quid chewing-related oral squamous cell carcinomas in Taiwan. Journal of the Formosan Medical Association 105(3): 229-234, 2006

Expression of p53 protein correlates with decreased survival in patients with areca quid chewing and smoking-associated oral squamous cell carcinomas in Taiwan. Journal of Oral Pathology & Medicine 28(2): 72-76, 1999

Survivin expression predicts poorer prognosis in patients with areca quid chewing-related oral squamous cell carcinoma in Taiwan. Oral Oncology 41(6): 645-654, 2005

MDM2 expression in areca quid chewing-associated oral squamous cell carcinomas in Taiwan. Journal of Oral Pathology & Medicine 30(1): 53-58, 2001

Upregulation of heme oxygenase-1 expression in areca-quid-chewing-associated oral squamous cell carcinoma. Journal of the Formosan Medical Association 107(5): 355-363, 2008

Expression of cyclin D1 is correlated with poor prognosis in patients with areca quid chewing-related oral squamous cell carcinomas in Taiwan. Journal of Oral Pathology and Medicine 28(4): 165-169, 1999

Infrequent p53 mutations in patients with areca quid chewing-associated oral squamous cell carcinomas in Taiwan. Journal of Oral Pathology & Medicine 28(5): 221-225, 1999

Chewing areca nut, betel quid, oral snuff, cigarette smoking and the risk of oesophageal squamous-cell carcinoma in South Asians: a multicentre case-control study. European Journal of Cancer 48(5): 655-661, 2012

Elevated snail expression mediates tumor progression in areca quid chewing-associated oral squamous cell carcinoma via reactive oxygen species. Plos One 8(7): E67985, 2014

The upregulation of metallothionein-1 expression in areca quid chewing-associated oral squamous cell carcinomas. Oral Oncology 44(2): 180-186, 2007

Heat shock protein 27 expression in areca quid chewing-associated oral squamous cell carcinomas. Oral Diseases 18(7): 713-719, 2013