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Prolactin receptor diversity in humans: novel isoforms suggest general principles



Prolactin receptor diversity in humans: novel isoforms suggest general principles



Trends in Endocrinology and Metabolism: Tem 13(2): 47-48



Novel short-form prolactin (PRL) receptors were recently identified in human tissues and cells. These receptor isoforms are analogous to rodent short PRL receptors that have long been known, but the splicing patterns for the human short PRL receptors are unique. The human short-form receptors compete with the signal-transducing long form for ligand, leading to reduced tissue sensitivity. The wide distribution of short PRL receptors in mammals suggests that tissues could use these 'decoy' receptors to adapt to the high lactogen levels that occur during pregnancy and lactation. It remains possible that such short-form receptors couple with unknown signal transduction pathways in some cells or species.

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Accession: 011209069

Download citation: RISBibTeXText

PMID: 11854013

DOI: 10.1016/s1043-2760(01)00558-6


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