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Pulmonary haemodynamic effects resulting from the obstruction of mediastinal lymphatic flow in anaesthetized rabbits



Pulmonary haemodynamic effects resulting from the obstruction of mediastinal lymphatic flow in anaesthetized rabbits



Medical Science Research 27(5): 345-348



The purpose of this laboratory study was to verify the hypothesis that if the mediastinal lymphatics were blocked, lymphoedema would occur mainly around the pulmonary blood vessels, and would increase pulmonary arterial pressure followed by pulmonary hypertension. The thoracic cavities of male Japan White rabbits (n = 20) were opened under general anaesthesia. Mediastinal lymphatic flow was arrested in the test group (n = 10). The values of the right ventricular systolic pressure with the average left atrial pressure 4+-1 mmHg (range 3-5 mmHg) were used to evaluate the difference between the test and control groups and between, before and after mediastinal lymphatic flow arrest. Lung water ratio was also measured in both groups. Histology of lung tissue was used to compare the two groups. The right ventricular systolic pressure in the test group after 4 h mediastinal lymphatic flow arrest increased by 4+-1 mmHg compared with the values before mediastinal lymphatic flow arrest. Histological investigation showed perivascular lymphoedema and endothelial injury in some segments of the pulmonary blood vessels in the test group.

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Accession: 011224921

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