+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Rapid screening for chiral separations by short-end injection capillary electrophoresis using highly sulfated cyclodextrins as chiral selectors



Rapid screening for chiral separations by short-end injection capillary electrophoresis using highly sulfated cyclodextrins as chiral selectors



Electrophoresis 22(15): 3203-3215



Two series of amino acid derivatives and phenylamines were used to evaluate the potential of highly sulfated cyclodextrins (HS-CDs) for the screening for chiral separations by capillary electrophoresis (CE). HS-CDs showed to be very versatile and to exhibit very high enantioselectivity. The use of short-end injection allowed to reduce dramatically the analysis time. From the results obtained, a scheme for the rapid screening of enantiomeric molecules was developed and applied to various chiral drugs. Results are very satisfying as almost all compounds (62 out of 67) could be baseline-resolved. Usually, less than three experiments were necessary to obtain very good separation.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 011246725

Download citation: RISBibTeXText

PMID: 11589281

DOI: 10.1002/1522-2683(200109)22:15<3203::aid-elps3203>3.0.co;2-g


Related references

Chiral separation of hydroxyflavanones in cyclodextrin-modified capillary zone electrophoresis using sulfated cyclodextrins as chiral selectors. Journal of Chromatography. a 1188(2): 301-307, 2008

Robustness testing of chiral separations by capillary electrophoresis using highly-sulfated cyclodextrins. Journal of Chromatography. A 1007(1-2): 165-177, 2003

A comparison of phosphated and sulfated beta-cyclodextrins as chiral selectors for capillary electrophoresis. Fresenius' Journal of Analytical Chemistry 369(5): 412-417, 2001

Fast chiral separations using sulfated beta-cyclodextrin and short-end injection in capillary electrophoresis. Journal of Chromatography. A 875(1-2): 403-410, 2000

Enantioseparation of phenothiazines in cyclodextrin-modified capillary zone electrophoresis using sulfated cyclodextrins as chiral selectors. Electrophoresis 26(20): 3869-3877, 2005

Determination of enantiomerization barrier of thioridazine by dynamic capillary electrophoresis using sulfated cyclodextrins as chiral selectors. Electrophoresis 30(17): 3071-3078, 2009

Application of sulfated cyclodextrins to chiral separations by capillary zone electrophoresis. Analytical Chemistry 68(8): 1360-1368, 1996

Comprehensive strategy for chiral separations using sulfated cyclodextrins in capillary electrophoresis. Chirality 15(8): 709-723, 2003

Optimization of enantiomeric separations for basic compounds in capillary zone electrophoresis using neutral and anionic cyclodextrins as chiral selectors. Biomedical Chromatography 9(6): 265-266, 1995

Strategies for enantioseparations of catecholamines and structurally related compounds by capillary zone electrophoresis using sulfated beta-cyclodextrins as chiral selectors. Electrophoresis 27(17): 3443-3451, 2006

Chiral separations by capillary electrophoresis using proteins as chiral selectors. Methods in Molecular Biology 243: 291-305, 2004

Chiral separations by capillary electrophoresis using proteins as chiral selectors. Methods in Molecular Biology 970: 377-392, 2013

A comparison of vancomycin and sulfated beta-cyclodextrin as chiral selectors for enantiomeric separations of selenoamino acids using capillary electrophoresis with UV absorbance detection. Analyst 125(2): 231-234, 2000

Chiral separation of abscisic acid enantiomers by capillary zone electrophoresis using cyclodextrins and their derivatives as chiral selectors. Analytical Letters 35(13): 2185-2197, 2002

Synthesis and application of single-isomer 6-mono(alkylimidazolium)-beta-cyclodextrins as chiral selectors in chiral capillary electrophoresis. Electrophoresis 26(20): 3839-3848, 2005