Section 12
Chapter 11,268

Regulation of c-Jun NH (2) -terminal kinase (Jnk) gene expression during T cell activation

Weiss, L.; Whitmarsh, A.J.; Yang, D.D.; Rincón, M.; Davis, R.J.; Flavell, R.A.

Journal of Experimental Medicine 191(1): 139-146


ISSN/ISBN: 0022-1007
PMID: 10620612
DOI: 10.1084/jem.191.1.139
Accession: 011267745

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The c-Jun NH2-terminal kinases (JNKs) are a group of mitogen-activated protein (MAP) kinases that participate in signal transduction events mediating specific cellular functions. Activation of JNK is regulated by phosphorylation in response to cellular stress and inflammatory cytokines. Here, we demonstrate that JNK is regulated by a second, novel mechanism. Induction of Jnk gene expression is required in specific tissues before activation of this signaling pathway.

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