Regulation of c-Jun NH (2) -terminal kinase (Jnk) gene expression during T cell activation
Weiss, L.; Whitmarsh, A.J.; Yang, D.D.; Rincón, M.; Davis, R.J.; Flavell, R.A.
Journal of Experimental Medicine 191(1): 139-146
2000
ISSN/ISBN: 0022-1007 PMID: 10620612 DOI: 10.1084/jem.191.1.139
Accession: 011267745
The c-Jun NH2-terminal kinases (JNKs) are a group of mitogen-activated protein (MAP) kinases that participate in signal transduction events mediating specific cellular functions. Activation of JNK is regulated by phosphorylation in response to cellular stress and inflammatory cytokines. Here, we demonstrate that JNK is regulated by a second, novel mechanism. Induction of Jnk gene expression is required in specific tissues before activation of this signaling pathway.
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