EurekaMag.com logo
+ Site Statistics
References:
53,517,315
Abstracts:
29,339,501
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Regulation of hemopexin synthesis in degenerating and regenerating rat sciatic nerve



Regulation of hemopexin synthesis in degenerating and regenerating rat sciatic nerve



Journal of Neurochemistry 72(2): 708-715



In injured peripheral nerves, hemopexin mRNA is expressed by fibroblasts, Schwann cells, and invading blood macrophages, and the protein accumulates in the extracellular matrix. This and its absence of regulation in injured central optic nerve suggest that hemopexin could play a positive role in peripheral nerve repair. Here, we studied the regulation of hemopexin expression in degenerating and regenerating nerves. After a sciatic nerve injury, both the synthesis of hemopexin and the level of its mRNA increase sharply during the first 2 days, leading to an accumulation of hemopexin in the nerve. Afterward, hemopexin expression decreases progressively in regenerating nerves. In permanently degenerated nerves, it is again transiently increased and then strongly decreased, whereas hemopexin from blood origin is accumulating. As part of the elucidation of the complex regulation of hemopexin expression in injured nerves, we demonstrate that interleukin-6 increases hemopexin synthesis in intact nerves, whereas adult rat serum, but not purified hemopexin, inhibits it in degenerated nerves. Hemopexin, known as acute-phase protein, is therefore one of the molecules rapidly and specifically up-regulated in injured peripheral nerves. More generally, our findings suggest that the acute phase could be not only a systemic liver-specific response but also a reaction of injured tissues themselves.

Accession: 011268877

Download citation: RISBibTeXText

PMID: 9930744

DOI: 10.1046/j.1471-4159.1999.0720708.x

Download PDF Full Text: Regulation of hemopexin synthesis in degenerating and regenerating rat sciatic nerve



Related references

Permeability of the blood-nerve interface to sodium in degenerating and regenerating rat sciatic nerve. FASEB Journal 7(3-4): A853, 1993

Changes in the concentration of enolase isozymes and S-100 protein in degenerating and regenerating rat sciatic nerve. Journal of Neurochemistry 40(4): 1076-1081, 1983

Levels of enolase isozymes and s 100 protein in degenerating and regenerating rat sciatic nerve. Neuroscience Letters. 14: S324, 1983

Changes in the concentration of enolase ec 4.2.1.11 isozymes and s 100 protein in degenerating and regenerating rat sciatic nerve. Journal of Neurochemistry 40(4): 1076-1081, 1983

Fine structural localization of cholesterol-1,2- 3 H in degenerating and regenerating mouse sciatic nerve. Journal of Cell Biology 52(3): 615-625, 1972

Fine structural localization of tritiated cholesterol 1 2 in degenerating and regenerating mouse sciatic nerve. Journal of Cell Biology 52(3): 615-625, 1972

Lipid content and phospholipid synthesis in degenerating sciatic nerve of dogs. Neurology 9(3): 184-186, 1959

Immunocytochemical localization of S-100b protein in degenerating and regenerating rat sciatic nerves. Journal of Histochemistry and Cytochemistry 37(4): 441-446, 1989

Ganglioside synthesis and transport in regenerating sensory neurons of the rat sciatic nerve. Brain Research 479(2): 277-282, 1989

Synthesis of myelin proteins and ultrastructural investigations in regenerating sciatic nerve of the rat. Journal of Neurochemistry 41(SUPPL): S131, 1983

Synthesis of myelin proteins and ultrastructural investigations in regenerating rat sciatic nerve. Journal of Neuroscience Research 13(4): 551-562, 1985

Effects of alcohol feeding on synthesis and secretion of apolipoproteins by regenerating rat sciatic nerve. Alcoholism, Clinical and Experimental Research 16(5): 899-903, 1992

Myelination of regenerating sciatic nerve of the rat lipid components and synthesis of myelin lipids. Neurochemical Research 8(2): 133-150, 1983

The histochemistry of neurokeratin in normal and degenerating sciatic nerve. Neurology 10: 365-371, 1960

The level of hemopexin, a glycoprotein absent from the CNS, increases after lesion and inflammation in the rat sciatic nerve. Society for Neuroscience Abstracts 21(1-3): 1073, 1995